Radiolabled Cyclopamine Assay for the Smoothened Receptor
The present invention discloses novel methods for screening compositions for both agonist and antagonist activity on the smoothened receptor. The assay tests ligands on the activity of the receptor using a cyclopamine binding and ultra high receptor expression.
CHEN WEI [US]; BARAK LAWRENCE S [US]; JIANGBO WANG [US]; LEFKOWITZ ROBERT J [US]; LEYRLY HERBERT KIM [US]
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