VHH Antibody Fragments for Use in the Detection and Treatment of Cancer
The presently disclosed subject matter provides ligands for detecting and imaging cancer cells and tumors, and for guided delivery of an active agent to cancer cells and tumors. In some embodiments the ligands comprise an antibody fragment, wherein the antibody fragment comprises a VHH domain. In some embodiments a composition is provided for targeting of cancer cells or tumors. Also provided are methods for delivery of a composition to a target tissue or tumor in a subject. Also provided are methods for imaging a target tissue or tumor in a subject. In some embodiments methods for treating a tumor in a subject are provided. Also provided are methods for diagnosing a tumor in a subject.
WO 2,010,042,815 [MORE INFO
PATZ EDWARD F JR [US]; GOTTLIN ELIZABETH B [US]; CAMPA MICHAEL J [US]
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