Cas6 Polypeptides and Methods of Use
Provided herein are methods for cleaving a target RNA polynucleotide. The target RNA polynucleotide includes a Cas6 recognition domain and a cleavage site, and may be based on a repeat from a CRISPR locus. The methods may be practiced in vivo or in vitro. Also provided are polypeptides that have Cas6 endoribonuclease activity in the presence of a target RNA polynucleotide, and methods for using the polypeptides.
WO 2,010,054,108 [MORE INFO
TERNS REBECCA M [US]; TERNS MICHAEL P [US]; CARTE JASON [US]
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