In Vivo Isotopic Labeling Method for Quantitative Glycomics
The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative/comparative analysis of glycomic compositions of biological cells. The method is applicable inter alia for identifying differentiated cells and their glycomic characteristics, differentiation conditions, disease and/or therapeutic progression, diagnosing disease states, determining drug activity, establishing manufacturing efficiencies and for determining the half-life of glycans in cells.
WELLS ROBERT LANCE [US]; ORLANDO RONALD C [US]; DALTON STEPHEN [US]; MOREMEN KELLEY W [US]; PIERCE J MICHAEL [US]; ATWOOD JAMES
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