Life Sciences Patents for Sale or License
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This invention is a response to COVID-19 for eradicating virus and bacteria on air and on surfaces. We have developed four product models based on our issued patent. (1) An ac operating pathogen disinfection station installed on a wheeled stand to be placed at the entrance way to disinfect people p...
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This invention is a response to COVID-19 for eradicating virus and bacteria on air and on surfaces. We have developed four product models based on our issued patent. (1) An ac operating pathogen disinfection station installed on a wheeled stand to be placed at the entrance way to disinfect people p...
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A method of producing a recombinant biological product, which method employs a mammalian producer cell culture, comprises the steps of generating a biomass of mammalian producer during an initial phase of cell culture, and causing an increase in a level of one or more of the miRNA molecules of Table...
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A method for providing nanoparticle clusters of controlled dimensions is described. The method involves an activation of individual nanoparticles and the subsequent interaction between activated particles to form a cluster....
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This is the only DNA gathering device of its kind. It allows the user to simply and effectively gather forensic evidence, without waiting for the sample to dry, or any extra steps to ensure the DNA sample does not become contaminated or degrade. It also can be stored at room temperature, without th...
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The invention relates to devices and methods for delivering nicotine and/or other alkaloids from tobacco, other plants and other natural sources. More particularly, the invention relates to devices and methods for delivering an aerosol of nicotine to a user's lungs without combustion of the nicotine...
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Methods for ameliorating a symptom associated with hypercholesterolemia, hyperlipidemia, or both in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiand...
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The present invention provides methods of treating, ameliorating or preventing hand-foot syndrome in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a phosphodiesterase inhibitor....
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The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention display selective inhibition of specific ...
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Localized drug delivery systems are effective means to administer therapeutic concentrations and controlled release of drugs. A delivery system consisting of non-ionic surfactant vesicles (niosomes) packaged within a biodegradable, temperature and pH sensitive hydrogel network was developed. Drug be...
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A drug delivery device has been designed to directly deliver an agent to the ovaries through direct contact with the fallopian tubes. The device consists of three main components: a tubular inserter, a cylindrical chamber and a plunger. The device is a single-use applicator designed in a shape simil...
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Disclosed are methods of predicting cell response to drug-based therapy using both PCR-Stop assays and real time PCR assays. Methods herein may be used for assessment of drug effect, evaluation of regimen suitability for a given patient, and/or for determination of an optimal drug dose. Also provide...
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The present invention relates to liquid sustained release suspension dosage forms comprising ionized forms of water-soluble drugs. In particular, the invention encompasses a liquid form controlled release drug composition comprising a dispersed phase comprising an ion-exchange matrix drug complex co...
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Carbohydrate functionalized catanionic vesicles that include a glycoconjugate and/or peptidoconjugate for vaccination or drug delivery, methods for forming these, and methods of using these....
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Disclosed are drug delivery compositions comprising an oligonucleotide-modified nanoparticle and a therapeutic agent. Specifically, disclosed are compositions comprising a number of oligonucleotide molecules in a ratio to therapeutic agent molecules to allow a sufficient transportation of the therap...
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Combinations of antiretroviral nucleoside reverse transcriptase inhibitors, and methods for their use in treating retroviral infections, are provided. In one embodiment, the combinations include non-thymidine nucleoside antiretroviral agents, such as tenofovir-DF, abacavir, APD and DAPD, that select...
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Conjugated compounds comprising a therapeutic or diagnostic agent linked to a substrate for a cell membrane transporter or receptor by lipophilic linker are provided....
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The present invention relates to aptamer/drug conjugate complexes and the use of such complexes, together with a trigger compound, to inducibly release a drug. Through these complexes, the present invention provides a means for establishing a drug reservoir in a subject, whereby drug may be released...
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The present invention relates to methods of decreasing the negative effects of alcohol on behavior as well as inhibiting the toxic effects of alcohol, comprising administering, to a subject, an effective amount of an inhibitor of phospholipase D....
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The present invention relates to anti-drug vaccines based on conjugates between the drug and a non-immunogenic carrier protein. In preferred embodiments, it provides for anti-cocaine vaccines and their use to diminish the effects and/or use of cocaine in a subject....
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Injectable or implantable drug delivery systems providing on-demand ultrasound- triggered drug release and methods for controlling the release of drug in a patient are provided herein. The on-demand drug delivery systems contain a drug depot and a drug encapsulated in an encapsulating material, wher...
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The present invention provides methods for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject. The present invention further provides methods for treating and preventing atrial and ventricular cardiac arrhythmias, heart failure, and exercise-induced sudden cardiac dea...
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The present invention provides novel 1,4-benzothiazepine intermediates and derivatives, methods for synthesizing same, and methods for assaying same. The present invention also provides methods for using these novel compounds to limit or prevent a decrease in the level of RyR2-bound FKBP12.6 in a su...
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The invention provides modified Transferrin (Tf) molecules and conjugates of the Tf molecules with a therapeutic agent. The invention also provides methods of treating cancer wherein the therapeutic agents are chemotherapeutic agents. The modified Tf molecules improve the delivery of the conjugated ...
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The invention relates to a method of engineering polar drug particles with surface-trapped hydrofluoroalkane-philes....
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Methods for identifying modulators of gastroesophageal smooth muscle relaxation include isolating various types of smooth muscle fibers from the stomach or esophagus and inducing the fibers to contract. The isolated and contracted fibers are used to screen test compounds for the compound's capacity ...
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A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed t...
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This disclosure relates, at least in part, to methods of eliminating adverse immune reactions in a subject in need thereof including those associated with autoimmune diseases, allergic reactions and transplant rejection, including administration of a lymphocytotoxic non-myeloablative amount of a oxa...
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Cullin5 (Cul5) E3 ubiquitin ligase is shown to be linked with the heat shock protein 90 (Hsp90) chaperone complex. Hsp90 participates in the folding of its client proteins into their functional conformation. Many Hsp90 clients have been reported to be aberrantly expressed in a number of cancers. Cul...
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This invention concerns an in situ biodegradable hydrogel drug delivery system in which the components are assembled in a manner that provides a mechanism for the timed cleavage of a particular amide bond in a covalently linked active agent or of the hydrogel structure....
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Biocompatible polyarylates of diphenol compounds and poly(alkylene oxide) dicarboxylic acids, articles formed therefrom and therapeutic uses are disclosed....
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Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with biocompatible diphenol corn-pound monomer units with pendant carboxylic acid ester groups and poly(alkylene...
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Extracellular matrix bioscaffolds capable of supporting the formation and growth of tumors from tumor cells introduced thereto containing tumor associated macrophages and carcinoma-associated fibroblast-like cells cultured under conditions effective to provide a cellular matrix capable of supporting...
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A dynorphin-A analog can be used for treatment, inhibition, and/or prevention of cocaine seeking behavior, and or the drug seeking behavior for a cocaine derivative or other structurally related substance. The dynorphin-A analog can be a cyclic dynorphin-A analog having sufficient systemic stability...
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The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell....
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A compliant composite for delivering a bioactive agent including a scaffolding material and a polymer coating that together can be attached to compliant tissue surfaces is disclosed, along with methods for constructing and applying these composites. In some embodiments, the composite further compris...
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The invention relates to polymers, such as aliphatic polyesters, with grafted zwitterions More particularly, the invention relates to polyester-graft-phosphorylcholine polymers prepared by ring-opening polymerisation and click chemistry, compositions and products comprising same, and related methods...
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The present invention provides a particulate delivery system comprising an extracted yeast cell wall comprising beta-glucan, a payload molecule and a payload trapping molecule. The invention further provides methods of making and methods of using the particulate delivery system....
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The present invention relates to a method for determining the susceptibility of a cell strain to a compound intended for controlling the growth of said cell strain, comprising: - growing the cell strain in a first compound-free culture medium and in at least a second culture medium comprising the co...
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Provided herein are methods for treating an individual having (suffering from) an acute myocardial infarction and drug eluting stents useful for treating such individuals. These methods include treating an individual by introducing, such as by surgically inserting, at a site of an acute coronary art...
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The invention relates to methods and kits for identifying individuals at risk of thiopurine drug intolerance based on detecting the presence of mutations in the TPMT gene promoter associated with thiopurine drug resistance or intolerance....
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The present invention relates generally to chemical compounds and methods for their use and preparation. In particular, the invention relates to chemical compounds which may possess useful therapeutic activity for treating conditions where the promotion of angiogensis (blood vessel formation) is ben...
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The present invention provides methods for the therapy and prevention of problem drinking in alcohol-dependent and non-dependent subjects and those at risk of developing problem drinking behavior, and compositions of matter comprising oxytocin or an analog or derivative thereof or an agonist or part...
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The present invention relates generally to the field of immunotherapy, and more particularly to immunomedicaments in the form of lipopeptides which induce an antibody response to drugs of dependence, and uses thereof in the treatment and prevention of drug addiction....
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A method for eliciting or inducing an immune response in a human or animal subject, comprises administering to said subject a composition comprising an antigen and an adjuvant, wherein the composition is administered to the subject by the intra-lung route....
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The specification relates to methods for treating a neurodegenerative disease such as multiple sclerosis by administering to a subject in need an EphA4 antagonist or an EphA4 ligand antagonist. The antagonist may be a soluble EphA4 or EphA4-binding ephrin or a functional variant thereof such as an E...
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PROBLEM TO BE SOLVED: To provide a method for treating neurodegenerative diseases such as multiple sclerosis by administering an EphA4 antagonist or an EphA4 ligand antagonist to a subject in need. ; SOLUTION: The antagonist may be a soluble EphA4 or EphA4-binding ephrin or their functional variants...
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The invention relates to a method for controlling the alertness of a human subject and a light source for use in this method and use of a light source for this method. The method comprises exposure of a human subject during an exposure period to suitable light radiation without substantially influen...
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Described are isolated peptides (GLGGGDLSV, SLNESQIKI, LMLPAVLQA and FTAEQLQRL) derived from portions of the Engrailed-2 (EN2) protein. Also described is their use in therapy, in particular in relation to the prevention and treatment of cancer....
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The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as "AAA compounds"), which, inter alia, are (selective) retinoic acid receptor a (RARa...
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An enclosure, method and apparatus for influencing the swimming behaviour of fish is disclosed. The enclosure defining a space within which the fish can swim, said enclosure having a series of light output members disposed along a path, said light output members being operable to provide a moving vi...
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The invention relates to a detection molecule (triplex Molecular Beacon, tMB) for detecting a particular nucleic acid sequence, in particular for detecting a single nucleotide mismatch in a target nucleic acid. Such a detection molecule comprises a) an oligonucleotide, and b) a probe comprising a fi...
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In the present invention, echogenic drug-loaded microbubbles are generated from stable micro- or nanoemulsions of perfluorocarbon upon injection into the body. This invention enables users to control the size of the emulsion droplets and bubbles by changing the concentration of a perfluorocarbon and...
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Recent advances in technology have led to methods for generating large sets of genomic and proteomic samples. This has created a need for tools that facilitate rapid screening and analysis of these large sets of samples. Immobilization of proteins and nucleic acids on a solid phase is a useful way...
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Antisense technology provides a platform for drug discovery as well as clinical therapeutic applications. Antisense agents (such as DNA, RNA, and ribozymes) bind to complementary regions on host nucleotides and thereby silence the expression of target genes. Given that target genes and their RNA t...
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The present invention provides a method of diagnosing equine hyperelastosis cutis (HC), an inherited connective tissue disorder of increasing prevalence in Quarter Horses. The diagnostic test includes determining the ratio of urine deoxypyridinoline (DPD) to pyridinoline (PYD) of a subject horse by...
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The present invention provides a novel method to use alkylaryl polyether alcohol polymers as antioxidants to block oxidant reactions and prevent tissue injury and disease that are related to overproduction of partially reduced dioxygen (O2) species, such as chronic pulmonary inflammation, myocardial...
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Dithiocarbarmate, particularly tetraethylthiuram disulfide, strongly inhibits the growth of a variety of cancer cells. The present invention provides a novel strategy for treating cancer, particularly metastatic melanoma, by using disulfiram to reduce tumor growth and to potentiate the effect of oth...
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In cancer treatment, a better understanding of the specific genetic and molecular changes that contribute to tumor growth is leading to the development of targeted therapies, which are predicted to be less toxic and more effective than current treatments. The efficient prescription of these therap...
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Proper DNA dosage is essential for normal and cellular development and function. Molecular approaches for the detection of chromosomal abnormalities will allow the development of rapid, cost-effective screening strategies. This invention describes a novel, rapid and highly accurate molecular tec...
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Much of biological activity is regulated through posttranslational protein modification in response to various stimuli. Proteins involved in cell proliferation, survival, migration, and shape can be controlled by reversible as well as irreversible modifications (i.e. phosphorylation, acetylation, g...
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This invention discloses an approach whereby the administration of a synthetic organic compound specifically induces proliferation of erythropoietin-producing peritubular interstitial cells in the kidney, which results in increased synthesis of erythropoietin. After cessation of treatment with the ...
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This invention describes a method for the high throughput qualitative and quantitative analysis of dicarboxylic acids, and in particular methylmalonic acid (MMA), which exploits the high specificity of tandem mass spectrometry and selective ionization of dicarboxylic acids. Vitamin B12 (cobalamin) ...
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The present technology provides novel engineered Saccharomyces cerevisiae (yeast) cell lines which are useful in bioassays for the identification and measurement of steroid hormone bioactivity in human serum. The yeast bioassay system has three functional units: a DNA-binding domain, a ligand-bindi...
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This invention pertains to conantokins, a subset of peptides isolated from cone snail venom. Conantokins are selective NMDA receptor antagonists that hold promise as antiseizure and analgesic therapies with fewer side effects than currently available treatments.
Benefits
� Epilepsy, characterize...
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The adenomatous polyposis coli (APC) gene is a tumor suppressor gene which is altered in many colon cancers. Germline mutations of APC are the cause of familial adenomatous polyposis (FAP), an inherited syndrome which leads to the growth of hundreds of colon polyps and a 100% lifetime risk of develo...
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The MCC gene is in close linkage with the adematotous polyposis coli (APC) gene on chromosome 5q21, a region of frequent loss of heterozygosity in colon cancer. MCC is found to be mutated in some colorectal tumors. Functional studies implicate MCC as a candidate tumor suppressor gene which plays a...
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The present invention provides a method for suppressing malignant melanoma proliferation by inhibiting NAD(P)H oxidase enzymes from generating reactive oxygen species (ROS). Malignant melanoma cells spontaneously generate ROS that promote constitutive activation of the transcription factor nuclear ...
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Uses of high throughput genomic technologies, including microarray technologies, are growing exponentially. One major limitation of current array technology is the poor predictability of hybridization signal intensity in relation to target concentration. Hybridization signal intensity change in re...
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Platelets are specialized blood cells that function in the formation of blood clots, and these cells act as the key cellular effectors of thrombosis. Tissue Factor (TF) is an essential cofactor for the activation of coagulation and clot formation. This work demonstrates that platelets express TF...
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Platelets are specialized blood cells that function in the formation of blood clots, and these cells act as the key cellular effectors of thrombosis. This work demonstrates that Cdc2-like kinase 1 (Clk1) mediated pre-mRNA splicing is an early control point in platelet activation, and is required ...
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Chronic lymphocytic leukemia (CLL), has the greatest prevalence rate among all leukemias. A significant limitation of both the existing staging systems for CLL is that they do not allow for reliable prediction of the rate of disease progression, or which patients are likely to respond to specific tr...
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The present invention provides the first and only genetic mouse model of synovial sarcoma, a highly aggressive, malignant childhood/young adult soft tissue cancer. This mouse model was generated by conditionally expressing the human SYT-SSX2 fusion protein with myoblasts. It faithfully recapitulate...
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Though oxidative stress is widely implicated in pathogenic states including aging and heart failure, the role of reductive stress, which is defined as the abnormal increase of reducing equivalents (e.g., glutathione, NADPH), remains controversial. The present invention provides genetic, molecular, a...
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Continued progression of prostate cancer during endocrine therapy is a major clinical problem. Hormonal treatment resistance and development of metastasis during the treatment have been linked to neuroendocrine cell differentiation within the prostate tumor. Prostatic neuroendocrine cells lack andro...
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The major inhibitory neurotransmitter in the brain is ?-aminobutyric acid (GABA), which primarily acts through GABAA receptors. Defective GABA neurotransmission causes neurological diseases such as anxiety disorders and epilepsy. GABAA receptor (ca 250 kD) is a ligand-gated chloride channel formed...
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The invention relates to a method of enriching a population of mammalian cells having an RNA interference (RNAi) sequence by providing eukaryotic (e.g., mammalian) cells containing a target gene. The invention defines a unique plasmid vector able to enrich siRNA-expressing cells to a high level of ...
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Genetic research has shown that variation or polymorphism in a gene may cause disease, increase risk of disease or affect response to therapeutic treatment of the disease. The particular combination of genetic polymorphisms at multiple loci is referred to as the �haplotype�. If an individual is het...
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Providing selenium in a nontoxic form is a distinct challenge. Organic forms appear to be superior to inorganic ones. This technology discloses a method for the design, synthesis and evaluation of prodrugs of selenocysteine. The prodrugs of selenocysteine may find wide utility in protection/preve...
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Endophytic fungi and bacteria are those organisms living within the tissues of host plants. Typically, endophytes coexist with their hosts without any pathogenic symptoms. These organisms have proven to be an unusually rich source of novel bioactive natural products. One of the most ubiquitous endo...
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Hepcidin is a liver-produced peptide hormone which controls iron absorption by regulating the amount of the cell surface iron transporter ferroportin, which exports iron from cells to blood. Altered hepcidin levels are associated with disorders of iron metabolism and absorption, and disease-associa...
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This technology comprises O-glycosylated cyclic peptides, including contulakin- G and derivatives isolated from cone snail venom. These show promise as therapeutics for pain, seizures, and other indications, and have an attractive safety profile.
Benefits
Potential therapeutic applications inclu...
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The present invention provides a new family of potent D-peptide inhibitors of HIV entry. These inhibitors have several advantages over Fuzeon, the only FDA-approved HIV entry inhibitor that is currently available. First, these inhibitors are resistant to proteases (potentially allowing oral bioavail...
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Ligand-gated ion channels are multimeric protein complexes, whose function depends on precise and correct ordered assembly of individual subunits. Using the nematode C. elegans as a model system for acetylcholine (ACh) gated ion channel formation, Dr. Jorgensen and colleague have identified a gene ...
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Natural Killer (NK) cells provide early defense against pathogens several days before the adaptive immune responses become operational. They are a type of lymphocyte responsible for destroying viruses and tumor cells. An NK cell kills a target cell by releasing perforin (and other molecules) which...
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HIV protects its conserved entry machinery with a steric block, preventing the binding of most antibodies. The present invention provides the methods of producing and identifying sterically restricted antigens that mimic this steric block for use as an antigen to select for antibodies that circumve...
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Signal transduction within and between cells mean that they can communicate important information and act upon it. Aberrant signal transduction is the cause of many of the most personally and financially devastating diseases including cancer, inflammatory diseases, cardiovascular disease and neurop...
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This invention demonstrates that purine nucleotides and dopamine modulate the odor sensitivity of peripheral olfactory receptor neurons (ORNs). Located in the dorsal recesses of the nasal cavity, these ORNs can be upward or downward modulated in sensitivity, by agonists and antagonists, respectivel...
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Since its discovery in the early 1980s, infection with HIV has reached epidemic proportions, especially in developing countries. Estimates suggest that 42 million people are living with HIV/AIDS worldwide, of whom around 3 million die each year. Current treatments involve a cocktail of drugs that ...
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Dr. Eric Schmidt and colleagues at the University of Utah have found a novel method to synthesize large libraries of amide-linked, modified cyclic peptides by expression of constructs in Escherichia coli.
Benefits
*Currently, technology to synthesize amide-linked cyclic peptide libraries is limi...
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Solvent extraction is an efficient method for selectively removing, purifying and concentrating certain elements or compounds from a solution because the solutes can be selectively removed and they can be concentrated from a very dilute stream.
Two types of solvent extraction systems are commonly ...
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This invention comprises a nucleic acid quantification kit and method for determining the initial concentration or mass fraction of a target nucleic acid present in a sample. More particularly, the invention relates to the use of real-time competitive quantitative polymerase chain reaction (PCR) an...
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Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland Security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to ana...
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The furanosteroids are a class of pentacyclic fungal metabolites that share in common a furan ring bridging positions 4 and 6 of the steroid skeleton. Members of this class are known for their powerful anti-inflammatory and antibiotic properties as well as their ability to selectively block certain ...
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Iron deficiency afflicts over 3 billion people worldwide, and plants are the principal source of iron in most diets. In response to iron deficiency, all plants except the grasses induce Fe(III) chelate reductase activity, Fe(II) transport activity and proton release into the rhizosphere. Dartmouth...
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Iron is an essential nutrient for all higher plants, with iron-containing compounds figuring prominently in the electron transport systems of photosynthesis and respiration. Although iron is abundant in the soil, the acquisition of iron is problematic due to its low solubility at biological pH unde...
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Pollution of the environment is one of the major problems facing the modern world. Removal of toxic metals poses particularly difficult problems, as unlike organic pollutants they cannot be biodegraded. Currently the standard way of removal of toxic metals from contaminated areas is by excavation ...
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Cellodextrins (-1,4-glucose oligomers) are of interest for investigating cellulase hydrolysis mechanisms and kinetics. In addition, cellodextrins have been used to investigate aspects of microbial cellulose utilization including regulation of cellulase synthesis, cell growth, and bioenergetics. Non...
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Motion sickness has been a long-standing problem for travelers, aviators and sailors. For some people, motion sickness symptoms can ruin a trip or even be disabling. Common remedies taken to prevent symptoms often have undesirable side effects.
Researchers at Dartmouth have discovered that ...
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Thionation, the conversion of a carbonyl group to the corresponding thiocarbonyl group, is a standard method for the preparation of a variety of useful organosulfur derivatives, including thionoesters, thionolactones, thioamides, etc. To date, the best reagent for bringing about this transformation...
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Technology Description A substantially purified high molecular weight cellulase enzyme having a molecular weight of between about 156,000 to about 203,400 daltons isolated from the bacterium Acidothermus cellulolyticus (ATCC 43068) and a method of producing it are disclosed. The enzyme is water ...
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Background Cancer is the second leading cause of death in the United States. As the number of diagnosed cancer patients increases, there is growing need for improved treatment strategies and imaging techniques for accurate cancer staging and detection. Platform technologies with the ability to both ...
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Background Currently, wet chemical conjugation and simple adhesion are used to achieve surface functionalization of biodegradable polymer particles. Unfortunately, both of these methods have poor reproducibility, they are inefficient, and they have complex processing requirements and toxicity issues...
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Background The use of antibacterial agents is widespread and can be seen in many products ranging from cosmetics to household cleaners. All tend to rely on alcohol- or triclosan-based ingredients to eliminate pathogens; however, the use of triclosan in antibacterial products has been suspected of ca...
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Background The identification and treatment of many life-threatening diseases such as cancer, heart disease, and atherosclerosis depends on the outputs provided by innovative medical imaging technologies such as optical coherence tomography, magnetic resonance imaging, photoacoustic imaging, ultraso...
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Background Despite enhanced understanding and the development of new therapeutic options, cancer remains a major cause of human morbidity and mortality worldwide. Early diagnosis of malignant events is the single most important factor determining survivability and long-term outcomes.
Much effort ...
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The resolution of conventional (far-field) optical microscopes is limited by diffraction to the wavelength of light. The near-field scanning optical microscope (NSOM), a recent advancement, obtains high-resolution images (typically 80-200 nm) by using probe light source, whose size and probe-to-samp...
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Background While there are many ways to synthesize nanoparticles, most have proven hard to solvate. Minor temperature flux can cause nanoparticles to drop out of solution, and current methods yield solutions that last only for a week and must be kept at low temperatures. This makes working with nano...
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Background Current drug delivery technologies rely on diffusion/degradation and are neither targeted nor stimuli-responsive. Further, several MEMS-based drug delivery devices have been formulated, but the efficacy of introducing these drugs to the patient has been compromised. Current technologies r...
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Background There is widespread optimism that nanosurgery will allow the improved resection of diseased tissues with minimal invasiveness and lessened collateral damage to adjacent healthy tissues. Initial methodologies involve localization of nanoparticles (generally gold nanoshells) to diseased tis...
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Background Nanoparticles have multiple applications in tissue targeted drug delivery, non-invasive monitoring of therapeutics, and as delivery devices. They also can be used by the cosmetics, agricultural and pharmaceutical industries to synthesize controlled release particles. Current methods used ...
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Background Nanoparticles have multiple applications in tissue targeted drug delivery, non-invasive monitoring of therapeutics, and as delivery devices. They also can be used by the cosmetics, agricultural and pharmaceutical industries to synthesize controlled release particles. Current methods used ...
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Background Currently, there is a rising problem of antibiotic resistance due to certain bacteria exhibiting immunity. Also, there are no completely efficient treatments or vaccines to prevent or treat viral diseases such as HIV, hepatitis C, and human papillomavirus.
Invention Description This t...
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Background Immunizations are an essential tool in the prevention of many infectious diseases. DNA vaccines offer great promise for safer and more effective vaccines when compared to traditional protein immunizations. Current technologies for the delivery of DNA vaccines involve the simple injection ...
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Background Current bioconjugates seem to be very unstable in the resulting product, which is a problem in creating a well-rounded nanoparticle. There is currently a need for a better process to inhibit the transmission of the AIDS virus in humans. Current bioconjugate techniques create dense nanopar...
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Background Current treatments for persons exposed to anthrax spores rely heavily on antibiotics to prevent the growth and ensuing toxicity of the anthrax bacteria; however, these treatments could be compromised through genetic engineering or the natural evolution of anthrax. There is a pressing need...
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Background Functional genomic disciplines seek to understand the contributions of genes and their protein products in healthy and disease conditions. Due to evolutionary conservation, model organisms provide simplified systems for analysis, while still producing relevant results. Gene function can b...
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Background Current treatments for persons exposed to anthrax spores rely heavily on antibiotics to prevent the growth and ensuing toxicity of the anthrax bacteria; however, these treatments could be compromised through genetic engineering or the natural evolution of anthrax. There is a pressing need...
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Background Influenza A viruses cause a highly contagious respiratory disease in humans that causes a significant loss of life each year, and dramatic mortality rates during human pandemics. H5N1 avian influenza A viruses, so-called bird flus, which have a human mortality rate of approximately 50% si...
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Background Currently, there is no way to produce complex eukaryotic proteins with multiple disulfide bonds in bacteria. This is because the bacteria cannot normally form the correct disulfide bonds in proteins, since they lack the appropriate enzymatic machinery for this purpose. Such proteins must ...
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Background Side effects and toxicity are a significant issue with many promising drugs. While a drug may remedy the targeted illness, serious side effects can, in some cases, be worse than the initial malady. In general, the side effects of a given drug are known, but may often be limited to a small...
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Background Sulfite hypersensitivity is an important problem for millions of people. Furthermore, a number of disorders in humans have been proven to be associated with allergic responses to sulfite. Sulfite forms naturally in the body during the oxidative degradation of sulfur-containing amino acids...
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Background Many elderly and sick people require oxygen-enriched air to facilitate breathing. Unfortunately, oxygen tanks are heavy and need to be refilled, limiting their convenience. Further, portable oxygen generators/concentrators (which generate oxygen from the surrounding air) are prohibitively...
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Background Coagulate vessels often need multiple treatments before they can be destroyed. Current technologies are limited by the finite penetration depth of light and by the natural flow characteristics of blood vessels in tissue. As a result, clinical procedures are often unsuccessful at treating ...
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Background The Centers for Disease Control and Prevention estimates that up to 20% of Americans contract influenza each year during flu season. Although most recover, it is estimated that 100,000 of those afflicted, have to be hospitalized, and about 36,000 people die from the virus each year in the...
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Background There have been few dramatic therapeutic breakthroughs in cancer research. Many more anticancer drugs are in use today than ever before, but nearly all of these drugs are severely limited in their use due to the dual problems of drug resistance and lack of selectivity. With cancer becomin...
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Background Nucleic acid-based therapeutics are rapidly becoming the next generation of drugs, offering promising potential for a variety of diseases. Antisense and small interfering RNAs (siRNA) "knock down" (dampen or decrease) the expression of specific, disease-related gene targets and have appli...
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Background There have been few dramatic therapeutic breakthroughs in cancer research. More anticancer drugs are in use today than ever before, but nearly all of these drugs are severely limited in their use, due to the dual problems of drug resistance and lack of selectivity. The guanine-rich ends o...
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Background Existing software that acquires event-related potentials from human subjects is mostly custom written by the user and not commercially available. Those that are commercially available only operate on specific hardware and only offer a single method for data evaluation.
Invention Descr...
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Background Sensors represent a billion-dollar market characterized by eleven product segments. Two of the sensor product segments are: 1. Proximity and displacement sensors and 2. Force and load sensors. (Global Industry Analysts, 2007) Types of proximity and displacement sensors include: inductive ...
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Background Functional genomic disciplines seek to understand the contributions of genes and their protein products in healthy and disease conditions. Due to evolutionary conservation, model organisms provide simplified systems for analysis, while still producing relevant results. Gene function can b...
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Background Functional genomic disciplines seek to understand the contributions of genes and their protein products in both healthy and disease conditions. Due to evolutionary conservation, model organisms provide simplified systems for analysis, while still producing relevant results. Gene function ...
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Background Numerous therapeutic proteins contain disulfide bonds. However, the production of proteins containing multiple disulfide linkages in genetically engineered bacteria is very inefficient. Bacteria are often not able to produce complex eukaryotic proteins in an active form and in high amount...
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Background The p53 gene is mutated in over half of all tumors, indicating its importance in the process of carcinogenesis. The gene encodes a tumor suppressing transcription factor that binds to certain DNA sequences, thereby activating a number of growth suppressing genes. There is a need to screen...
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Invention Description APEx is a validated method to isolate binding polypeptides, including antibodies or antibody fragments, that recognize specific molecular targets. A library of polypeptide (e.g., antibody) mutants is constructed and expressed in E. coli bacteria. The mutant polypetides are expr...
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Background The FDA currently requires pharmaceutical firms to create enantiomerically pure substances, or that the enantiomer of the drug be thoroughly studied and found to have no adverse side effects. The synthesis of enantiomerically pure substances requires the use of reagents that give enantiom...
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Background Bacterial fermentation remains a popular and reliable form of protein production for both research and commercial applications. Current systems require complementary functional elements present in both engineered bacterial strains and plasmid expression vectors to insure tight control on ...
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Background In laser dermatological and oncology treatments, absorbed radiant energy generates an increase in temperature to heat targeted structures. However, before performing laser therapy, it is important to identify the appropriate laser dosimetry required to heat targeted structures and protect...
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Background Almost 81 million individuals in the United States suffer from a form of cardiovascular disease that cost over $400 billion yearly in the United States alone. Coronary heart disease is the number one cause of death in America. Market priorities are to obtain accurate representations of th...
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Background There is widespread optimism that nanosurgery will allow the improved resection of diseased tissues with minimal invasiveness and lessened collateral damage to adjacent healthy tissues. Initial methodologies involve localization of nanoparticles (generally gold nanoshells) to diseased tis...
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Background Even with the completion of the human genome sequence, the functions and interactions of most encoded genes have yet to be uncovered. Understanding the role of genes and gene networks underlying human development, the onset and progression of disease, and our responses to environmental st...
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Background Conventional methods for tissue repair involve sutures, staples, or clips. By their very nature, they result in a "foreign body" being left in the tissue. Tissue injury and foreign body reaction can give rise to such problems as inflammation, granuloma formation, scarring, and stenosis. I...
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Background According to the American Cancer Society, approximately 2.5 million cases of cancer were diagnosed in the US in 2007 (including basal and squamous cell epithelial cancers), of which 85% originated in the epithelial tissue layer. Diagnosis, early detection, and treatment of diseases at an ...
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Background Bioelectronic interfaces hold great promise for medicine and research; however, current fabrication methods for electronic or electroactive materials typically involve expensive lithographic masks, complicated stamping, and chemical etching. The assemblies produced via this route are inhe...
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Background Bacteria are a common source of recombinant proteins for a variety of research, therapeutic, and vaccine applications. Recombinant proteins accumulating intracellularly often form insoluble inclusion bodies. Extraction of properly folded recombinant proteins from inclusion bodies is a com...
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Background Organ failure and tissue loss account for half the medical spending in the United States. In theory, transplantation is the last therapeutic option available to people in the final stage of an organ or tissue failure. The supply of organs or tissues is so limited that for the vast majorit...
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Background Approximately eight million surgical procedures are performed annually in the United States to treat tissue damage resulting from accidents, birth defects, hereditary disorders, and other diseases. Because traditional tissue repair procedures are inefficient, potentially painful to the pa...
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Background Current methods for CO2 removal are not only very expensive but also cause large losses of gas and the use toxic chemicals. Furthermore, most polymer membranes used for purification are more permeable to small molecules (e.g. H2) than to larger molecules (e.g. CO2). Less permeability then...
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Background Certain sequences of DNA are able to form unique, G-quadruplex structures. These structures are implicated in a variety of biological processes. One example of such a process is the cancer-cell specific elongation of chromosome telomeres by the enzyme telomerase. G-quadruplex structures h...
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Background A major drawback to the use of SAM as a medicament is its expense: present methods of production rely on the chemical transformation of methionine, which is an expensive starting material. If a more cost effective method of production were realized, this valuable amino acid could be more ...
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Background The current method used to convert a,ß unsaturated ketones into a hydroxy ketones or a hydroxy esters results in only moderate selectivity with a low yield. Also, the effectiveness of some contraceptives and hormonal treatments can stand to be improved.
Invention Description The proce...
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Background The new use of known materials to prepare pyrroles in a highly efficient and selective manner is the nature of the discovery.
Invention Description A new method for the synthesis of pyrroles from nitriles and cyclopropanes is described. Pyrroles have found applications as pharmaceutic...
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Background Bioelectronic interfaces hold great promise for medicine and research; however, current fabrication methods of electronic or electroactive materials involve expensive lithographic masks, complicated stamping, and chemical etching. The assemblies produced are inherently 2-D and have not pr...
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Background Current controlled-release drug delivery technologies rely on diffusion/degradation, and are not physiologically responsive. Several MEMS-based drug delivery devices have been formulated, but the efficacy of introducing these drugs to the patient has been compromised. Also, current techno...
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Background Currently, wet chemical conjugation and simple adhesion are used to achieve surface functionalization of biodegradable polymer particles. Unfortunately, both of these methods have poor reproducibility, they are inefficient, and they have complex processing requirements and toxicity issues...
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Background Ricin is a potent heterodimeric cytotoxin easily isolated from the seeds of the castor plant, Ricinus communis. The protein consists of a lectin B chain, which can bind cell surfaces and is linked by disulfide bonds to an A chain (RTA), which enzymatically depurinates a key adenine residu...
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Background Nanoparticles have multiple applications in targeted drug delivery and non-invasive monitoring of therapeutics. The benefits of nano-based drug delivery extend to treatments for infectious diseases as well as cancer, cardiovascular, metabolic, and neurological diseases. Market-driven prio...
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Background Nanoparticles have multiple applications in tissue targeted drug delivery, non-invasive monitoring of therapeutics, and as delivery devices. They also can be used by the cosmetics, agricultural and pharmaceutical industries to synthesize controlled release particles. Current methods used ...
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Background Therapeutic peptides and proteins such as insulin are difficult to deliver through the digestive tract, so they are usually delivered by injection. Inhalation offers a much simpler, painless and effective alternative. Highly porous micron-sized aggregates of protein nanoparticles have the...
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Background Immunizations are an essential tool in the prevention of many infectious diseases. DNA vaccines offer great promise for safer and more effective vaccines when compared to traditional protein immunizations. Current technologies for the delivery of DNA vaccines involve the simple injection ...
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Background The development of microarrays is of crucial importance in genomics for genome sequencing or for the determination of gene expression, in proteomics for the identification of pathologic markers, and in biomedical analysis for the realization of point-of-care diagnostics.
There is a nee...
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Background Cancer is the second leading cause of death in the United States; early detection is the key to treatment. In humans, 85% of all cancer originates in the epithelial tissue, including the esophagus, colon, lung, bladder, and cervix. There is currently no way to detect and locate these canc...
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Background An orphan G-protein coupled receptor (GPCR) has previously been shown to be involved in estrogen signaling in breast cancer cells. Also, this GPCR has been suggested to be the membrane estrogen receptor (mER) mediating these estrogen effects. However, no reports were available demonstrati...
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Background The U.S. market for medical imaging equipment increased from $6.7 billion in 2005 to an estimated $7.8 billion in 2007. It should reach $11.6 billion in 2012, a compound annual growth rate (CAGR) of 8.1%. Medical imaging has brought about great improvements in the quality of health care. ...
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Background The detection of lesions on mammography is a repetitive and fatiguing task. Only three or four out of a thousand examined cases are malignant, and thus an abnormality may be overlooked. As a result, radiologists fail to detect 10% to 30% of cancers.
Computer-Aided Detection (CADe) syst...
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Background The sensitive and accurate detection of spores and other infectious agents is essential in clinical environments and biodefense applications. Because of the excellent sensitivities obtained, polymerase chain reaction (PCR) methods are widely used for detection purposes. However, many diff...
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Background Current Alzheimer's disease (AD) diagnostic tools which utilize biological markers have low rates of success or involve invasive techniques that are at best uncomfortable and unreliable. Other tools incorporate bulky and expensive machinery. Moreover, many of the latter tests rely on the ...
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Background The American Cancer Society shows 15 million people were diagnosed with oral cancer in 2004. Cancer cure and survival rates are tied directly to the stage of the cancer at the time of diagnosis. Early detection in many cases can permit minimally invasive treatment and greatly improves lon...
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A murine monoclonal antibody (mAb) directed against the human CD13 antigen has been developed at Northwestern University. MAb 3D8 appears to be myeloid restricted, reacting with myeloid cell lines, peripheral blood monocytes, and macrophages of the reticuloendothelial system and lung. However, this ...
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Researchers at Northwestern University have created a unique transgenic mouse model that expressed superoxide dismutase (SOD). This is an excellent animal model for the analysis of Cu- or Zn-superoxide dismutase in amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, which is a pro...
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This invention describes antibodies directed against heat shock factors, HSF1 and HSF2. HSFs (also designated heat shock transcription factors) are involved in the transcriptional regulation of heat shock proteins (HSPs) which are rapidly induced in organisms in response to various environmental and...
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This invention describes a novel mAb, KPL1, that completely blocks the interaction of PSGL-1 with either L-selectin or P-selectin leukocyte adhesion molecules. KPL-1 is therefore useful in studying interactions between leukocytes and either platelets, endothelium or other leukocytes. KPL-1 has prove...
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Recently researchers at Northwestern University have developed a function blocking monoclonal antibody (mAb) to the a4 subunit of laminins. This antibody, mAb 2A3, inhibits angiogenesis and endothelialization in vitro and in vivo.
SCIENTIFIC BACKGROUND: Integrins are cellular receptors that medi...
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Northwestern investigators have developed a high-throughput screening method for novel genes and/or drug compounds associated with the sleep and wake state. Previously it has not been possible to screen a large number of sleep-related drugs and/or genes in rodents because of the time, cost and invas...
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Investigators at Northwestern University have invented a novel system appropriate for the high-throughput analysis of gene function and an approach for the controlled, efficient delivery of DNA or oligonucleotide (ON) complexes from a surface, from which multiple genes or ONs can be delivered in par...
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To discover new lead compounds for drug design, large libraries of chemical compounds are screened for their ability to modulate receptor and enzyme protein activity and function. The screens for such compounds are performed experimentally (high throughput screening) or computationally (virtual scre...
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To discover new lead compounds for drug design, large libraries of chemical compounds are screened for their ability to modulate receptor and enzyme protein activity and function. The screens for such compounds are performed experimentally (high throughput screening) or computationally (virtual scre...
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Tau-13 is a mouse monoclonal antibody (mAb) that binds to human tau as demonstrated by ELISA and immunoblot assays and is able to stain brain tissue early in Alzheimer’s disease. The Tau-13 mAb would be useful to researchers who wish to detect human tau in solid phase assays as it has a remarkably h...
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This invention describes a number of monoclonal antibodies (Mabs) specific to the different subunits of laminin-5 and hemidesmosomes (HDs). These monoclonal antibodies may be used to study epithelial cell motility, cell proliferation, cytoskeleton formation, cell adhesion, and the process of wound h...
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Investigators at Northwestern University have identified several novel genes that effect dehydration resistance in nematodes: when expression of these genes is modulated, parasitic and beneficial nematodes have altered sensitivity to dry, high salinity environments. In particular, knocking out these...
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INVENTION: Novel liposomes have been developed that are useful as non-viral vectors to deliver DNA to cells. The invention described herein focuses on the use of lipoplexes with incorporated microtubule disrupting agents as non-viral gene delivery vectors that can efficiently and non-toxically deliv...
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Investigators at Northwestern University have identified that beta-blocker drugs are effective inhibitors of malarial infection in vitro and in vivo. Beta blockers are inexpensive, approved to treat cardiac indications, non-toxic, and otherwise well-tolerated in patients. Research and development e...
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Robert C. MacDonald et al., developed novel liposomes useful as transfection agents to deliver nucleic acids to cells for which efficient transfection with conventional agents is difficult. The novel transfection agent, MLS, is a mixture of two cationic components (L and S) that are combined in diff...
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INVENTION: Investigators at Northwestern University have synthesized a new class of zinc-chelating probes that are useful as ratiometric probes for zinc (Zn(II)). The development of this probe allows the use of a new research reagent to be utilized in the investigation of the functions of zinc in bi...
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Recently, a new antibody specific for caspase cleaved Tau was developed at Northwestern University. This antibody Tau C3, is a mouse monoclonal antibody (mAb) that binds to human tau truncated at aspartic acid 421 as demonstrated by ELISA and immunoblot assays. The antibody stains amyloid beta treat...
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Northwestern investigators have created novel "thermo-gelling" polymer networks for use as DNA sequencing matrices for high-throughput microchannel electrophoresis in capillary arrays. Capillary array electrophoresis with these networks provides efficient resolution of both small and large DNA seque...
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A mouse monoclonal antibody specific for residues 9-18 in the amino terminus of tau. The antibody is of the IgG1 isotype and is phosphorylation independent. This epitope is lost after cleavage at Asp13 by caspase-6.
SIGNIFICANCE: Previous work has shown that loss of Tau-12 immunoreactivity in t...
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Although uterine artery embolization (UAE) is widely used clinically, an animal model containing actual uterine fibroids does not exist. Development of such an animal model would be desirable as a platform for interventional radiologists to a) test embolic therapies; b) determine the most appropriat...
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A mouse monoclonal antibody (IgG1) to detect nitration in a protein-specific and site-selective manner. This antibody recognizes tau only when nitrated on residue Tyr29. It does not cross react with wild type tau, tau mutants singly nitrated on Tyr18, Tyr197, and Tyr394, or other proteins known to ...
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A self-assembling liquid polymeric system for the synthesis of robust sacs and string membrane structures having properties suitable for cell and therapeutic delivery, diagnostic and tissue repair applications.
ADVANTAGES: Facile generation of biocompatible membrane structures with excellent mech...
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INVENTION: Müller cells are the most abundant non-neuronal cells in the vertebrate retina. It is known that they perform a variety of functions that support the activities of retinal neurons, but there has been little progress in elucidating the mechanisms underlying these functions. Primary culture...
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INVENTION: Researchers at Northwestern University have isolated a novel molecular motor molecule, Prestin, from outer hair cells (OHCs) of the mammalian cochlea. This unique biological motor is capable of direct, rapid, electro-mechanical conversion without dependence on ATP. The ability of this mol...
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INVENTION: The “BioChip” invention electronically detects biomolecules and toxic agents. When a target species chemically binds to the surface of a tiny cantilever probe, the probe deflects and the BioChip electronically measures and reports that deflection. The BioChip presents the following advant...
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INVENTION: This invention is a novel glucose sensor that uses the hydrogen-specific gas sensing capability of single walled carbon nanotubes (SWCNT’s) assembled on a microelectrode. The conductivity of SWCNT’s changes due to adsorption of hydrogen that causes the energy band structure of SWCNT’s to ...
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INVENTION: Northwestern researchers have synthesized a new cathode, Ag4V2O6F2, (SVOF) with significantly higher accessible silver content than current medical battery cathodes employing silver vanadium oxide (SVO). Greater capacity and potential are produced compared to SVO. In addition the chemical...
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INVENTION: Northwestern researchers have created a surface-enhanced Raman biosensor for use in detecting and identifying Bacillus anthracis, a spore-forming bacterium and dangerous pathogen for the disease anthrax. The system promises the potential for detecting other hazardous microorganisms.
AD...
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INVENTION: A thin biocompatible wafer with millions of micron-size channels has been designed to allow for efficient transport in artificial organs. This wafer may be significantly important in artificial lung design.
BACKGROUND: A major function of most internal organs (e.g., lungs, kidneys, liv...
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INVENTION: Scientists at Northwestern have created surface-enhanced Raman biosensors for detection of in vivo and ex vivo analytes. In particular, the present invention provides a technology for the in vivo detection of blood glucose.>/p>
ADVANTAGES: A potentially faster, easier, and less painfu...
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INVENTION: Ag2V4O11 (SVO) and Ag4V2O6F2, (SVOF) are important cathode materials for medical battery applications such as defibrillators. A one-step process has been developed affording crystalline SVO and SVOF by reaction under ambient conditions, eliminating the need for superambient pressure and t...
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INVENTION: A novel battery cathode composition having a higher discharge capacity available from silver reduction at a potential above 3V compared to that of the current standard medical battery cathode SVO material.
ADVANTAGES: Batteries incorporating the new cathode exhibit a potential above 3...
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INVENTION: Northwestern researchers have developed peptoid mimics of antimicrobial peptides that can be immobilized onto surfaces, rendering these surfaces capable of compromising the membranes of attached bacteria.
ADVANTAGES: Peptoids afford promising alternatives to conventional antimicrobial...
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This is the extension of the bridging centrality network to biological networks. In the network representation, proteins and other biological molecules are the nodes of a network and the interactions between the molecules are the edges connecting nod es. The degree of a node and and centrality have ...
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Summary Background: In small molecule drug development, researchers typically develop biased libraries in which all members share a particular characteristic, such as an ability to interact with a particular target ligand or structural features designed to mimic a particular aspect of a class of nat...
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Summary Background: In Multiple Sclerosis, the host’s immune system (lead by T cells) attacks and destroys myelin basic protein, the principle component necessary for nerve transmission. Part and parcel of this immune response pathway are the so-called Major Histocompatibility Complex (MHC) molecu...
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Summary A bacterial toxin has been shown to enhance immune reactions to adipocytes when injected locally, facilitating antibody-mediated and complement-dependant cytolysis.
Applications A peptide therapeutic for localized delivery for the ablation of fat cells. Results from localized injection si...
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Summary Background: Autophagy is the process by which cells cannibalize cellular elements such as proteins and organelles to generate intracellular metabolites for cell survival and cell death. For example, a cell undergoes autophagy for architectural remodeling during development or to eliminate da...
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Summary A method of screening for compounds that modulate SIRT4 fatty acid oxidation activity.
SIRT4 is a mitochondrial protein that plays a central role in regulating amino acid stimulated insulin secretion (AASIS) in pancreatic ?-cells by inhibiting glutamate dehydrogenase and impacting fatty a...
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Summary A new paradigm in cell death has been discovered, Necroptosis. Necroptosis reflects a distinct mechanistic pattern of programmed cell death that combines elements of passive unregulated necrosis and organized, energy-dependent apoptosis. Activated by the TNF family, sterols, and toll-like re...
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Summary Activated ras genes have been associated with a number of human cancers. An activated ras gene, H-ras-1, was the first non-viral oncogene discovered. Several other human ras proto-onco genes have subsequently been identified including H-ras-2, K-ras-1, K-ras-2, and N-ras. Activated K-ras gen...
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Summary Mariner-family transposable elements are active in a wide variety of organisms and so are important genetic engineering tools. The Himar1 element, isolated from the horn fly, Haematobia irritans, has been shown to be active in E. coli. Hyperactive variants of the corresponding transposase ha...
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Summary A high throughput system for protein purification has been developed, whereby a “tea-bag†structure is used to house microspheres for targeted protein binding and elution. The microspheres are compatible with any solid-phase protein purification, which includes coupling of Ni++/Histidine...
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Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications. Currently, many laboratory processes can be combined on a single chip commonly only millimeters in size while manipulating liquid volumes of picoliter size or less. In order to effectively...
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Introduction Impaired blood flow and mitochondrial defects are involved in a wide variety of metabolic and degenerative diseases. The inability to quantify tissue hemoglobin (Hb) content presents a significant barrier to non-invasive assessment of regional mitochondrial function in blood flow. Techn...
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Introduction Cardiovascular disease (CVD) is the leading cause of death among both men and women in the United States and, as such, is associated with high costs in terms of health care, morbidity, and mortality. An important aspect of the fight to reduce CVD is the development of diagnostic tests t...
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Introduction High density lipoprotein (HDL) protects against atherosclerosis by removing cholesterol from cells of the artery wall. Apolipoprotein A-I (apoA-I), which accounts for ~70% of the total protein in HDL, promotes cholesterol and phospholipid efflux largely by an active transport process. T...
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Introduction Because of their small sizes and unique properties, nanomaterials are finding widespread use in studying complex biological systems. Gold nanostructures have been the subject of intensive research because of their unique and tunable surface plasmon resonance (SPR) properties. Because of...
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Introduction Saccharomyces cerevisiae, or budding yeast, is a single-cell eukaryotic microorganism that commonly is used by biologists to study genetics. Yeast pedigree analysis is used to study genomic instability associated with aging and cancer and involves the isolation and characterization of t...
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Introduction Multiple drug resistance is a well-documented phenomenon and critical problem in the treatment of various diseases including cancer and HIV. While there are many mechanisms leading to multiple drug resistance, one area of focus is the MDR1 gene and its protein product P-glycoprotein (Pg...
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Introduction With the introduction of screening mammography, the median tumor size has decreased considerably, and approximately half of breast cancers in surgical practice are non palpable and amenable to breast conserving surgery. Traditionally, non palpable lesions are excised with a wire or wire...
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Introduction The invention relates to DNA vaccines, or vaccines containing molecules encoded by such DNA, for the induction of specific, sustained high titer antibody responses. More specifically, the invention is directed to DNA vaccines that comprise recombinant expression constructs encoding a ce...
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Introduction Diseases of the liver, both genetic and acquired, are especially detrimental due to the fact that the liver is a key organ for most metabolic pathways. Currently, the only method of curing liver diseases is via a liver transplant. Unfortunately, many transplants succumb to rejection, le...
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Introduction 35 novel thymidylate synthase (TS) mutants have been generated by random mutagenesis. These mutants are different from wild type TS in single, double, or multiple mutations, which are located distant from the active center. The new TS mutants reveal enhanced resistance to TS-inhibiting ...
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Introduction Vaccines often require the use of adjuvants, immune modulating substances, to generate adequate immune responses for the prevention or treatment of disease. Current adjuvant systems often display toxic properties, can be unstable, and can have unacceptably low immunostimulatory effects....
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Introduction Novel methods for the detection, monitoring, treatment, and prevention of malignancies have been developed that are based on the body’s own immune response to cell surface markers on cancer cells. Technology description Detection of the proliferation of T-cells in response to in vitro e...
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Introduction Pancreatic cancer is a highly lethal disease; it is highly invasive and unresponsive to standard chemotherapy. The discovery of genes that cause familial forms of cancers has often shed light on the biology of the sporadic form of the disease. University of Washington researchers have i...
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Introduction Approximately 30,000 women are diagnosed with ovarian cancer yearly in the United States, and only about 50% of those diagnosed will survive the disease. Early, accurate prognosis of ovarian cancer is closely related to stage of the disease at diagnosis. It is estimated that about 106,0...
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Introduction Recent developments have firmly established the important role of receptor tyrosine kinases in human cancer. Kit is a receptor tyrosine kinase and its role as a cellular oncogene has been established in a number of cancers including gastrointestinal stromal tumors (GISTs), which belong ...
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Introduction In addition to surgery, many cancers are also treated with a combination of therapies involving cytotoxic chemotherapeutic drugs and/or radiation therapy. However, disadvantages to this method are that radiotherapeutic and chemotherapeutic agents are toxic to normal tissues, often have ...
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Introduction Thyroglobulin is a marker of thyroid cancer. The presence of thyroglobulin in the plasma/serum of patients indicates functioning thyroid tissue. Following surgery and treatment with radioactive iodine, patients with thyroid cancer should be free of all functioning thyroid tissue. Detect...
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Introduction Minimally invasive surgery is now being used routinely as one of the most preferred choices for various types of operations. Despite its many advantages, such as reduction of trauma, less pain, smaller injuries, faster recovery time, and reduction of postoperation complications, MIS dec...
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Introduction Myeloperoxidase (MPO) co-localizes with macrophages in the human artery wall, and its characteristic oxidation products have been detected in atherosclerotic lesions. Thus, oxidants produced by the enzyme might promote atherosclerosis. However, macrophages in mouse atherosclerotic tissu...
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Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is point-of-care diagnostic devices. These devices provide fast, accurate, and inexpensive sample analys...
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Introduction Low levels of high density lipoprotein (HDL) are associated with a greatly increased risk of coronary artery disease (CAD). Evidence indicates that HDL protects against atherosclerosis by removing cholesterol from macrophages in the artery wall. In vitro studies indicate that chlorinati...
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Introduction Warfarin is an anticoagulant used to prevent the blood from forming dangerous clots that could result in stroke. Determining the most effective and safest dose for each patient is extremely complicated and time consuming as warfarin metabolism varies greatly between patients and is affe...
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Introduction The level of cholesterol in the blood is an important risk factor for atherosclerosis and coronary artery disease (CAD) which can eventually lead to heart attack or stroke. Cholesterol is present in many forms, the most familiar of which are the lipoproteins LDL and HDL. As atherosclero...
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Introduction HIV patients are currently treated using “HAART,” a highly active anti-retroviral therapy in which a plethora of drugs are administered to patients. This therapy is effective in reducing virus concentration in the blood, however, studies have shown that levels in the lymph nodes do not ...
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Introduction Alveolar hypoxia, as occurs with chronic lung diseases or ascent to high altitude, results in hypoxic pulmonary vasoconstriction (HPV). Exaggerated HPV causes high altitude pulmonary edema
(HAPE) and may complicate the course of patients with chronic cardiopulmonary disease. HPV is bel...
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Introduction Acute injuries to smaller blood vessels and subsequent dysfunction of the tissue in which the injured blood vessels are located (microvascular angiopathies) are common features of a variety of diseases of different organs, such as kidney, heart and lungs. A subgroup of such diseases is ...
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Introduction Paraoxonase 1 (PON1) is a member of a three-gene family localized on human chromosome 7. Due to its role in the metabolism of both lipids and organophosphorus
(OP) compounds, genetic variability in PON1 has been examined by many research groups as a risk factor for vascular and other d...
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Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will enable faster, cheaper, and more accurate patient evaluation for a wide array of parameters. One such p...
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Introduction The breast cancer resistance protein (BCRP) is an ATP-binding cassette efflux transporter originally identified by its ability to confer multidrug resistance in cancer cells. BCRP mediates the efflux transport of a broad spectrum of substrates, including many drugs routinely administere...
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Introduction Osteoporosis, an age-related disease in which loss of bone mass causes skeletal deformities and fractures, affects nearly 20 million people in the US, mostly women. A major complication is a fracture of the thigh bone, in which case 20-30% of patients die in the year following the fract...
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Introduction The olfactory sensory system has the remarkable capacity to detect and discriminate among a wide array of odorants and translate them into cognitive representations. Cyclic nucleotide–gated ion channels in olfactory sensory neurons (OSNs) are hypothesized to play a critical role in olfa...
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Introduction The presence of histochemically reactive zinc within synaptic vesicles defines a subset of neurons that have been termed zinc-enriched (ZEN) neurons. Because ZEN neurons are prevalent throughout the limbic system and zinc is capable at physiological concentrations of exerting neuromodul...
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Project 1: We currently are marketing / outlicensing a diabetic food additive / neutraceutical. Possible Drug development aspects.
Project 2: We are looking for a grant, an angel investor(s) and/or venture capital group to bring to NCE status a new drug to treat and prevent Alzheimers. If you ...
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Novel neuroprotective peptide agent capable of reducing the amount of ischemic brain injury. Description
Researchers at the Centre for Addiction and Mental Health have developed a novel neuroprotective peptide agent capable of reducing the amount of ischemic brain injury. This is accomplished b...
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The Lincoln, Nebraska-based Office of Technology Development (OTD): http://otd.unl.edu/ manages the intellectual property assets of the University of Nebraska-Lincoln. OTD’s mission is to help turn academic research into tangible products and services, while returning income to the inventors and to ...
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Novel small chemical compounds capable of disrupting the three key misfolded proteins responsible for Alzheimer’s disease (AD) and other CNS disorders Description
Our researchers have created novel small chemical compounds capable of disrupting the three key misfolded proteins responsible for A...
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Upsher-Smith Laboratories, Inc., is a privately held, specialty pharmaceutical company with headquarters in Minneapolis, MN (www.upsher-smith.com). The company is seeking collaborative partners and out-licensing opportunities for improved drug therapies that treat epilepsy, Parkinson's and Alzheimer...
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Upsher-Smith Laboratories, Inc., a privately held, specialty pharmaceutical company with headquarters in Minneapolis, MN (www.upsher-smith.com), is actively seeking Canadian companies or research organizations with technology or expertise in various areas of drug delivery. Background
Upsher-...
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Upsher-Smith Laboratories, Inc., a privately held specialty pharmaceutical company with headquarters in Minneapolis, MN (www.upsher-smith.com), would like to augment its current portfolio with marketed or near-to-market women’s health products. Upsher-Smith Laboratories, Inc., a privately held spec...
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BACKGROUND In the last 10 years commercial interest in treatment of spinal degeneration in relation to back pain has increased with a large number of devices competing in a market estimated to be worth more than $3.5bn and growing at 15 - 20% pa. This technology being developed at the University of ...
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BACKGROUND Neuroleptics are the drugs of choice in the treatment of schizophrenia, bipolar mania and related disorders but suffer from troublesome side-effects such as drug induced parkinsonism, restlessness, facial tics etc. The severity and patient acceptability of these effects varies widely. Res...
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BACKGROUND Although there is considerable research being carried out in the area of hollow sub-micron constructs for the purposes of encapsulation of useful therapeutic entities, most of the processes developed to date for the preparation of such constructs are incompatible with maintaining the func...
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BACKGROUND Gastrointestinal nematode infections are amongst the commonest infections of man and animals worldwide. Collectively 1 in 3 people on the planet are infected by at least one species and approximately 50% of these are school age children In the developing world they affect the well being o...
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BACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-microbial products, for out-licensing to healthcare companies across a range of sectors. THE TECHNOLOGY ...
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BACKGROUND Pre-designed self-assembling scaffolds are highly advantageous in a number of areas, including tissue regeneration, 3D cell culture, in vitro toxicity testing and understanding of cell/extracellular matrix interactions. Self-assembling peptides, with the various properties of amino acids ...
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BACKGROUND A research project in in the Faculty of Life Sciences at the University of Manchester has led to the development of a novel yeast-based drug delivery mechanism. THE TECHNOLOGY A genetically engineered yeast strain, able to express recombinant protein drugs / vaccines and incorporating a g...
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BACKGROUND Research at the University of Manchester has identified a new tissue marker with potential use in the stratification of breast cancer patient groups and improved targeting of treatment for each patient. THE TECHNOLOGY The human homolog of the suppressor of deltex protein (SDRP) is aberran...
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The Invention The invention describes a new, reliable and efficient method for mapping and quantifying the contribution of elements to the overall performance of the system they compose.
The Need With the genomic revolution a huge amount of data has become available concerning the expression of...
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A novel genetic system for the elimination of tannins in edible plant materials such as canola seeds and sorghum seeds has been developed. This involves genetic engineering of these plants such that they accumulate a tannin-detoxifying agent. The Need Global agricultural production is greatly infl...
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The Invention Plant viruses and viroids exploit plasmodesmata nano-channels as conduits for viral spread. Plasmodesmal proteins, endogenous to plants, have been modified such that they permanently block plasmodesmata nano-channels. This blockage inhibits plant virus spread: a major cause of reduced...
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The Invention A technology was developed enabling the domestication / commercial husbandry of S neapolitana - The optimal pest control for marine aquaria.The novel technology includes special culture media for propagating the distinct nudibranch life cycle stages, and unique culture apparatus for p...
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DOMAIN Aging of injuries on a victim’s body is an important aspect of forensic medicine. Currently, visual assessment and colorimetry based on empirical criteria are the most common techniques for this task, although the results are uncertain. The aim of this study was to develop a mathematical mode...
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DOMAIN Although the incidence of gastric carcinoma (tumour in stomach) is declining, this disease is still the second most frequent cause of cancer death worldwide. Gastric carcinomas are often not detected until at an advanced stage; consequently, the 5-year survival rates are low and most often in...
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DOMAIN The mucosal surfaces of the body (such as GI tract, respiratory tract, eye, and genitourinary tract) constitute the major target for drug and gene delivery. As such, mucous secretions can have a significant influence on drug/gene complex uptake. These effects of mucus are usually more pronoun...
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DOMAIN The study of gene expression in cells is increasingly being used to understand their biological function. The genes are up- and down-regulated by a complex protein regulatory network, which responds to the biochemical changes originating from within and outside the cell. One of the most popul...
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DOMAIN In many situations it would be beneficial to have an instrument that can show In biology and medicine, fluorescent labelling is used to detect the location and concentration of various molecules. This can be used to discover how molecules are interacting in relation to diseases and biological...
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In many situations it would be beneficial to have an instrument that can show directly the spatial distribution of various chemical components in real time of a surface. Typical application areas are forensic and military where investigators can rapidly locate the presence of blood, gunpowder, toxic...
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DOMAIN An early and accurate detection of cerebral palsy (CP) enables correct treatment at an early age to the infant at risk. Today’s methods for detecting CP are unable to establish a diagnosis until late in the first year of life, in some cases even later. Experts are currently doing analysis of ...
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DOMAIN Within an ageing population, ischemic heart disease (IHD) and secondary heart failure represent major challenges underlining a demand for diagnostic imaging to identify IHD in its different stages and forms. There is also a need to diagnose heart failure developing after myocardial infarction...
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Determining the severity of a leakage through a heart valve is important. There are several parameters that are clinically interesting in this regard: the area of the lesion, the flow or flow rate through the lesion and the geometry of the lesion. These three parameters are not easy to measure. Curr...
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DOMAIN Glycosylases have found use in a number of methods aimed at analyzing DNA for the presence of altered nucleobases that could result from ionizing radiation or chemical oxidants, identifying mismatched base pairs, studying repair of abasic sites in double-stranded DNA and as a means to prevent...
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