Donor Organ Preservation for Transplantation Using a Hemoglobin Based Solution
During heart transplantation, the heart must be preserved while it is transported from donor to recipient. Standard techniques call for the heart to be immersed and cooled in cardioplegia or saline solution. Unfortunately, this method does not deliver necessary oxygen, nutrients, and electrolytes to the heart. Newer methods of preservation have focused on creating blood-like substitutes. At the University of California, Irvine, researchers have formulated a solution that significantly lengthens the time a heart can be preserved. This solution was formulated to provide oxygen, electrolyte balance, and nutrients to the heart during transport. This invention will allow sufficient time for complex tissue typing, allow better donor-recipient matching, and allow for transportation of hearts to more distant sites. In addition, this formulation has the potential to be used as a blood substitute during open heart surgery or surgery of any sort.
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