Use of Infectious and Pathogenic Clone of a Lung Cancer-Inducing Retrovirus for Generation of Therapeutic Reagents and Diagnostic Tests
Background: Jaagsiekte sheep retrovirus (JSRV) causes broncheolo-alveolar carcinoma in sheep and is a significant veterinary problem world-wide. Clinically and histopathologically, this disease has strong resemblance to broncheolo-alveolar carcinoma (BAC) in humans which accounts for approximately 25% of human lung cancers. Technology: Researchers at the University of California, Irvine have isolated the first infectious molecular clone of JSRV and have developed techniques for production of infectious JSRV that allowed the researchers to prove that JSRV alone was sufficient to induce BAC in sheep. Application: The molecular clone of JSRV has potential for the generation of diagnostic reagents for infection in sheep, the generation of vaccines against JSRV, and the generation of novel retroviral vectors for targeting lung tissue. Finally, this line of research can serve as a starting point for searching for analogous viruses in human.
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