Non-scattering Oxygen Carrying Media for Intravascular Optical Coherence Tomography Imaging
Background: If blood is replaced locally in the vascular system by injection of saline solutions, OCT images can be obtained for brief periods of time, but lack of oxygen is deleterious to the tissues, and ischemia and damage will result, compromising patient health, as well as the OCT images obtained. There is a need for a replacement media which could deliver/make available oxygen to tissues while they are imaged by OCT. Technology: University of CA researchers have developed a clear media through which to obtain OCT images and a source of oxygen for the tissues under observation. The invention covers the use of non-scattering, oxygen carrying media in conjunction with optical coherence tomography (OCT) probes to enable OCT images to be obtained within the circulatory system including blood vessels and the heart. without ischemic damage to the tissues under observation. OCT probes can be placed in a catheter or through a needle and introduced into blood vessels. Injection of the non-scattering, oxygen containing solutions can be accomplished simultaneously through the same or parallel catheter systems. The solutions are injected, clearing away the blood for a brief period of time to allow CT images to be obtained. These solutions are compatible with blood, and will mix and dissipate in a short period of time. Multiple injections/infusions of these solutions can be used to obtain the diagnostic OCT images desired.
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