Photoacoustic Indicators

This disclosure presents a method for using agents such as organic dyes, dye-embedded nanoparticles and metal nanoparticles as sensing agents for deep in-vivo tissue imaging. The agents The agents provide image contrast based on a specific parameter of the tissue such as: pH, calcium ion concentration, magnesium ion concentration, cell membrane potential etc. The method employs photoacoustic imaging to provide both deep tissue imaging and optical contrast. The agents act as photoacoustic sources changing their signal generation efficiency as a function of the specific external parameter, thus providing an image of the distribution of biologically relevant parameters in living tisusue. Implications for medical diagnostics and therapy include early cancer detection and therapy personalization (tailoring dose and therapy type to patients based on functional imaging).

Inventor(s): Shai Ashkenazi,Gwangseong Kim,Thomas D. Horvath,Russell Witte,Raoul Kopelman

Type of Offer: Licensing



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