Energy-Saving Technological Method for Long-Term Storage of Bio-Degradable Tissue
Background: Currently the critical storage of bio-degradable tissue for long periods of time is done at -70" C. This temperature does provide nearly unlimited storage time. Storage at -70' C is substantially more expensive as compared with that at -40" C Technology: The crucial part of this proposal is based on the idea that while the initial cooling to the temperature where the flip-flop will be accomplished (to or below approx. -70" C) is obligatory, this low temperature is not obligatory for the further long-term storage, which could be maintained at much higher (by approx. 30" C) temperature. The feature, which enables this is the hysteresis observed in glass transition, when the curve describing the changes upon heating is different from that during cooling - the former lags behind the latter. Application: The idea of this proposal - to use specific thermodynamic and kinetic properties of the glass transition for biomaterial storage. The expected advantage is that the implementation of our method would make it possible to supplement the long-term storage at -70" C with that at -40" C, bringing energy savings. Any storage of bio-degradable tissue which is nowadays done at -70" C, especially that where the absence of degradation is extremely critical: health-care providers, pharmacological industry, biomedical companies.
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