Edible Anti-Adhesion Material Derived from Cranberry for the Treatment of Helicobacter Pylori Infection

The Invention An edible, high-molecular-weight, non dialyzable material (NDM) isolated from Cranberry juice inhibits specific adhesion of H. Pylori to immobilized human mucus and to cultured gastric epithelial cells. No relationship was observed between the resistance to antibiotics and the anti-adhesion effect of NDM. The anti-adhesion activity of NDM provides a novel approach for the treatment of gastric ulcers caused by H. Pylori.
The Need Helicobacter Pylori (H. Pylori) is the major cause for a variety of gastro-intestinal diseases including gastric, duodenal and peptic ulcers. Current treatment regimens for H. Pylori infections are complex and difficult to complete. In many patients prolonged exposure to antibiotic therapy may cause Candida infections and/or antibiotic resistance.
Potential Applications NDM interrupts H. Pylori adhesion to humane gastric mucus and cells. It may thus be used for treatment of gastric ulcers.
Advantages NDM represents a new approach for the treatment of H. Pylory infection:

o It can be administered in various ways suitable for gastro-intestinal therapy

o It is edible

o It is not bactericidal and therefore selection for resistant strains or fungal infections is not anticipated
Stage In-vitro studies have been performed using various clinical isolates of H. Pylori. Most of the strains were sensitive to inhibition by NDM.
References o "A high molecular mass constituent of cranberry juice inhibits helicobacter pylori adhesion to human gastric mucus" FEMS immunol Med Microbiol 2000 Dec;29 (4):295-301.

o "Inhibition of helicobacter pylori adhesion to human gastric mucus by a high-molecular-weight constituent of cranberry juice" Crit Rev Food Sci Nutr 2002;42 (3 Suppl): 279-84.
Patent Pending Tech Transfer Officer Dr. Nissim Chen Office: +972-3-6406121 Fax: +972-3-6406675 Mail: chen@ramot.org

Inventor(s): Itzhak Ofek, Ervin Weiss

Type of Offer: Licensing



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