Targeted Nanoparticles for Drug Delivery

Invention Novel particulate drug delivery technology comprises of lipidated Glycosaminoglycan, that form micro or nano particles in a controlled manner. The particles (neither a liposome nor a microsphere/nanosphere) can encapsulate DNA, proteins and small molecules with high efficiency and perform in vivo as targeted, site-adherent, site retaind, sustained-release drug depots. In vivo studies with encapsulated chemotherapeutics have demonstrated that these particles are long-circulating, actively target their entrapped drugs to tumors, and significantly improve clinical indicators such as circulating time, tumor size, tumor growth rate and long-term survival
The Need Current particulate systems for drug delivery such as micro- and nano-spheres, viral envelopes and liposomes suffer from disadvantages including: stability and biocompatibility problems, low efficiency of encapsulation and poor targeting properties. New efficient drug delivery systems that adequately address these issues are desperately required in fields as diverse as cancer therapy, diagnostic imaging and gene therapy.
Potential Applications
· Tumor therapeutics

· Drug targeting and sustained release

· Systemic and/or topical drug delivery

· In vivo imaging

· Gene therapy
Advantages
· Provide active targeting

· Suitable for systemic and local administration

· Slow release

· Biocompatible

o Non-toxic

o Non-immunogenic

o Biodegradable

· May overcome drug resistance
Stage Cumulative data includes structural and physicochemical characterization and formulation of a wide rang of drugs: DNA, small molecule drugs, peptides and proteins. Extensive mechanistic and functional in vitro and in vivo studies have been performed, showing among other aspects that these particles facilitate and increase drug entry into target cells, and that the system is not toxic. In vivo studies using MDR tumors in both syngeneic mice and human xenografts models, nano particles encapsulating Doxorubicin and Mitomycin C demonstrated active targeting of entrapped drugs to tumors, as well as improved clinical indicators. We have also developed methods for the encapsulation of poorly water soluble drugs, such as taxol, in these novel nano particles. Current studies demonstrate high encapsulation efficienc, exceptionally-high taxol loading and retention of (encapsulated) drug activity.
Patent Pending Tech Transfer Officer Dr. Nissim Chen Office: +972-3-6406121 Fax: +972-3-6406675 Mail: [email protected]

Inventor(s): Rimona Margalit, Dan Peer

Type of Offer: Licensing



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