Design of Surface Plasmon Biosensor Based on Self-Referencing and Digital Window System
Introduction Surface Plasmon resonance (SPR) has attracted strong attention as a biosensor in the past two decades because it can provide label-free, real-time detection with high sensitivity. Technology description Researchers at the UW have developed an SPR biosensor with increased accurate referencing. In this design sensing and referencing materials are prepared adjacently in one channel so the bulk affect for the sensing and referencing surface are almost the same. As a result, a more precise SPR signal shift can be obtained. Business opportunity SPR can be used to measure the change in refractive index during adsorption of cells and proteins. From these data properties such as mass and thickness of adsorbed layers can be deduced. Also conformational changes in the internal structure of the layers can be seen, which is invaluable information in the exploration of binding-behavior of proteins and cells. Stage of development Initial data and working prototype exist for this technology. Intellectual property position This technology is available for licensing. The UW is currently reviewing this technology for worldwide patent protection.
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