Precision coating of macromolecules on Surfaces
Introduction Production of chemically modified surfaces by ion deposition allows for unique chemistries on those surfaces, providing functionalities that are critical to medical devices such as stents and vascular grafts. Sophisticated materials are now required for complex medical applications such as implant biocompatibility and biosensing as well as passive functions like sterility. Technology description Researchers at the University of Washington have developed a process and apparatus for depositing ionized molecules, including biomolecules, onto a surface and after plasma-treating that surface. The key advantages of this combination approach include the ability to deposit large molecules while retaining the bioactivity of the molecule. Both enzymes and long-chain biopolymers have been successfully demonstrated, and many other types of modifications are possible. In addition, the technique offers the ability to optically steer singly- or multiplycharged ions onto a chemically modified surface. This spatial maneuvering allows for very fine control of ion deposition. Furthermore, polymer film coatings can be created that are not possible with wet chemistry or other existing techniques. Business opportunity This approach and instrument will be particularly useful in coating medical devices such as vascular grafts, stents, and interventional cardiological devices. Device coating is the most rapidly expanding sector of the $213B medical device industry. Stage of development Initial data and working prototypes exist for this technology. Surface properties have been verified by in-vitro studies. Intellectual property position The UW has US and foreign patents pending for this technology.
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