Genes Encoding Telomere-Associated Proteins
APPLICATIONS OF TECHNOLOGY:
- Molecular biology research - Medical research
ABSTRACT: Telomeres are believed to be critical regulators of the genome, and telomere stability important for preventing cancer and ageing. Regulation of telomere length is believed to be controlled by multiple telomere-associated proteins. Using a previously cloned human telomere binding protein, Berkeley Lab researchers Sahn-ho Kim and Judith Campisi cloned two novel human telomere-associated proteins, TANK-2 and TIN-2. The full length sequence of one, and a partial sequence of the other is known. TANK-2 and TIN-2 may be important telomere regulators, and therefore of interest in the health care arena for the diagnosis or treatment of cancer or age-related diseases.
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