Cyclic nucleotide phosphodiesterase 7B (PDE7B)

Introduction Cyclic nucleotide phosphodiesterases (PDEs) are enzymes hydrolyzing the second messengers adenosine and guanosine 3',5'-cyclic monophosphates (cAMP and cGMP). The human genome encodes 21 PDE genes that are categorized into 11 families. Selective inhibitors against individual PDE families have been developed as therapeutics for treatment of various human diseases. Technology description This technology provides the mouse cDNA clone for PDE7B, a cAMP specific PDE. In mice, PDE7B transcripts are rich in the pancreas and can also be found in the brain, heart, thyroid, and skeletal muscle. Related Publication(s)
Proc. Natl. Acad. Sci. USA 2000 Jan 97(1): 472-476

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