SV2B Knockout Mouse

Introduction Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein found only in the secretory vesicles of neural and endocrine cells. It appears to be unique to vertebrates, suggesting that it evolved as a part of complex signaling systems. In mammals, there are three SV2 genes denoted A, B, and C. The molecular mechanism by which these proteins regulate secretion is not clear. Based on predicted structure and amino acid sequences, the SV2 proteins belong to the major facilitator superfamily of transporter proteins, although no transport substrate has been identified despite substantial effort. SV2B is brain specific, with a wide but not ubiquitous distribution. Technology description Dr Sandra Bajjalieh’s laboratory has generated SV2B knockout mice. After homologous recombination in embryonic stem cells, cell lines carrying the SV2B disruption were injected into C57BL/6 blastocysts and implanted into pseudopregnant females. Loss of SV2B does not affect viability or fecundity of the mice. This transgenic mouse offers a powerful tool for investigating how the loss of SV2 affects neural signaling in brain networks. Related Publication(s)
Proc Natl Acad Sci U S A 101(26): 9861-6, 2004. The Journal of Neuroscience 26(4): 1303-1313, 2006. For more information on this technology contact:

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