PDL2-Ig Fusion Protein

Introduction T cell activation and tolerance are critically regulated by costimulatory molecules, especially those in the B7 and CD28 superfamilies. PD-1, a novel member of the CD28 family, is expressed on activated T cells and B cells. PD-1 has been shown to be a negative regulator of T cell activation and is crucial for maintaining immune tolerance. PD-1 deficiency in mouse results in spontaneous autoimmune diseases. Moreover, PD-1 deficiency or blockade accelerated autoimmune diabetes on NOD background. Blocking PD-1 also enhanced experimental autoimmune encephalomyelitis (EAE) disease. Two ligands, B7-H1_PDL1 and PDL2_B7DC, have been found to bind to PD-1. Technology description PDL2- Ig fusion protein was generated in Dr Chen Dong’s lab and can be potentially used to generated monoclonal antibodies. Related Publication(s)
Immunity, Volume 18, Issue 6, Pages 863-873

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