HEK293T cells stably expressing Divalent Metal Transporter-1 (DMT1-1): Model System to Screen for Inhibitors of Iron Uptake

Summary A HEK293T cell line that stably expresses Divalent Metal Transporter-1 (DMT-1). DMT1 functions in transport of ferrous iron across the plasma membrane and/or out of the endosomal compartment. Thus, the cell line is an ideal tool to screen for potential iron transport inhibitors. In one example, the cell line was used to screen two bioactives libraries for DMT-1 iron uptake inhibitors. Several potential hits were found, including one that may be specific for the DMT1 iron uptake pathway.

Applications Cell-based screen that enables the rapid identification of iron transport inhibitors. From initial efforts, 10 small molecule inhibitors of transport have been identified, and ongoing studies focus on characterizing their mechanisms of inhibition. For Further Information Please Contact the Director of Business Development Vivian Berlin Email: [email protected] Telephone: (617) 495-0474

Inventor(s): Wessling-Resnick, Marianne

Type of Offer: Licensing



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