Animal Model of Diabetes and Obesity: Cross-bred JNK1 KO/JNK 2 KO Mice

Summary Mice with the JNK 1 and JNK2 genes knocked out were crossed with the obese mouse line (ob/ob) to create a mouse model of diabetes and obesity. These mice exhibit many of the hallmark metabolic pertubations characteristic in diabetes and obesity.

Nature: Vol 420, Nov 21, 2002, pp 333-336

Applications These mice are a research tool that can be used to screen therapeutic compounds for efficacy in diabetes and obesity. For Further Information Please Contact the Director of Business Development Vivian Berlin Email: Telephone: (617) 495-0474

Inventor(s): Hotamisligil, Gokhan S.

Type of Offer: Licensing

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