A Novel Class of Phospholipase A2 Preferentially Expressed in Th2 Cells

Summary This invention describes the identification of a novel, low molecular weight class of Phospholipase A2 enzyme, PLA2 Group XII, that is involved in Type 2 T helper (Th2) cell differentiation and activity. This enzyme provides a potential target for therapeutic modification of Th2 activity, including prostaglandin production and Th2-mediated immune response.

Applications This invention encompasses the isolation and use of PLA2 GXII nucleic acids and proteins, including transgenic animals and pharmaceutical preparations and/or applications, antibodies against PLA2 GXII, compounds that modify PLA2 GXII activity and the methods of identification and use of such compounds. For Further Information Please Contact the Director of Business Development Vivian Berlin Email: vivian_berlin@harvard.edu Telephone: (617) 495-0474

Inventor(s): Ho, I Cheng

Type of Offer: Licensing



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