Methods to Regulate the Duration of Th2 Activation

Summary TID1 encodes two human mitochondrial matrix localized splice variants. Expression of each of two splice variants has opposing effects on the cell's ability to respond to exogenous apoptotic stimuli. TNF and mitomycin c both trigger apoptosis via hTID1(L) expression. Both forms affect cytochrome c release, as well as caspase 3 activation; neither affect caspase 8 activation. The accumulation of hTID1(s) in Th2 cells following activation represents a novel mechanism that may contribute to the induction of apoptosis resistance during the activation of Th2 cells.

Applications Cell death or survival:
-desensitization to apoptotic signals -survival of degenerating tissue -neurodegeneration protection -chemotherapeutic against viral infection -chemotherapeutic against cancer cells For Further Information Please Contact the Director of Business Development Michal Preminger Email: [email protected] Telephone: (617) 432-0920

Inventor(s): Munger, Karl

Type of Offer: Licensing



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