Hyperactive mutant of the Himar1 mariner transposase
Summary Mariner-family transposable elements are active in a wide variety of organisms and so are important genetic engineering tools. The Himar1 element, isolated from the horn fly, Haematobia irritans, has been shown to be active in E. coli. Hyperactive variants of the corresponding transposase have been isolated. These proteins retain their hyperactivity and are useful both in vivo and in vitro as research tools and in cell-based manufacturing processes.
See Lampe et al., 1999, Proc. Natl. Acad. Sci. USA 96(20): 11428-33.
The invention is protected under U.S. Patent No. 6,368,830, which is available for non-exclusive license.
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