A Device for Allocation of Frozen Biological Samples Such as Blood and Tissues

Summary The frozen sample aliquotting instrument will extract aliquots from frozen samples such as plasma and serum without thawing the sample. This represents a new approach for biorepositories that will ensure that samples will experience only one freeze/thaw cycle, and dramatically reduce the labor and time required to process orders for samples while also cutting order fulfillment by five weeks. Additionally, the frozen aliquotter will reduce the amount of freezers and freezer space needed in a biorepository because the sample can be stored in larger volumes.

Proof of principle in key areas has been demonstrated:
-To maintain the sample at -70°C for several hours -To extract 100µl aliquots from plasma frozen at -70°C with a CV of less than 7%
-To manage frost buildup during processing

Applications Commerical applications include a frozen sample aliquotter with a target market of biological repositories both large and small.

Biorepository growth will continue to grow at 15% per anum as pharmaceutical companies expend their discovery programs to incorporate personalized medicine in their drug development pipelines. The NCI biorepository is reported to grow at over 20% year-over-year. For Further Information Please Contact the Director of Business Development Katie Gordon Email: katherine_gordon@hms.harvard.edu Telephone: (617) 432-0920

Inventor(s): Larson, Dale N.

Type of Offer: Licensing



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