AlignAce motif searching software

Summary Developed by genomics researchers at Harvard Medical School, AlignAce employs an algorithm that scans non-coding nucleic acid sequences at high resolution for motifs that occur with non-random frequency. This algorithm is built into a multi-level sequence analysis program that highlights gene-specific regulatory elements for further analysis.

AlignAce offers both efficiency and convenience. Its high signal-to-noise ratio preferentially reduces false positives in the program output, while iterative masking uncovers multiple, distinct sequence motifs within a single data set. In gene expression studies, Alignace easily highlights potential gene regulatory elements and sets of co-regulated genes. Nucleic acid sequences identified by AlignAce may be used as drug targets or, alternatively, as bait to isolate gene-specific trans-regulatory proteins for use as drugs or drug targets.

Reference:

Roth, F.P., Hughes, J.D., Estep, P.W. and G.M. Church, 1998,

"Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation", Nat. Biotechnol.16(10): 939-945. (See also, "Comment", pp. 907-908.)

AlignAce is available to commercial users for inspection purposes only at:

http://arep.med.harvard.edu/mrnadata/mrnasoft.html

Applications Genomics and gene regulatory analyses for basic research or drug development. For Further Information Please Contact the Director of Business Development Maryanne Fenerjian Email: [email protected] Telephone: (617) 432-0920

Inventor(s): Church, George M.

Type of Offer: Licensing



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