SV2A Knockout Mouse

Introduction Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein found only in the secretory vesicles of neural and endocrine cells. It appears to be unique to vertebrates, suggesting that it evolved as a part of complex signaling systems. SV2A was shown to be the binding site for the antiepileptic drug levetiracetam, suggesting that it plays a role in modulating neuronal excitability. Indeed, gene disruption studies indicate that SV2 is essential for survival and for normal nervous system functioning. Technology description Dr Sandra Bajjalieh’s laboratory has generated SV2A knockout mice. After homologous recombination in embryonic stem cells, four cell lines carrying the SV2A disruption were injected into C57BL/6 blastocysts and implanted into pseudopregnant females. One of ten chimeric males produced offspring heterozygous for the SV2A gene disruption. These offspring were bred with each other to produce animals homozygous for the mutation. Wild-type offspring of heterozygotes were used to establish a colony of genetically matched control animals. This transgenic mouse offers a powerful tool for investigating how the loss of SV2 affects neural signaling in brain networks. Related Publication(s)
PNAS 96(26): 15268-15273, 1999. The Journal of Neuroscience 26(4): 1303-1313, 2006. For more information on this technology contact:
Ariadna Santander Agreements Manager Technology Licensing [email protected] 206-543-1138

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