Cell line stably expressing rat cardiac sodium channel α subunits (Nav1.5)

Introduction The Nav1.5 sodium ion channel protein is an integral membrane protein and tetrodotoxinresistant voltage-gated sodium channel subunit. The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Technology description Dr William Catterall’s laboratory has generated a chinese hamster lung 1610 cell line stably expressing Nav1.5 from rat. This cell line is useful for screening compounds against cardiac ion channels. Related Publication(s)
PNAS 1994 91: 3289-3293. For more information on this technology contact:
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