Clonal Cell Lines Expressing Sodium Channel RIIA (Nav1.2) and Subunits

Introduction Voltage-gated sodium channels are responsible for action potential initiation and propagation, placing them in ideal position to regulate firing and conduction in neurons. Nav1.2 (rat brain type IIa) represents a highly tetrodotoxin (TTX)–sensitive sodium channel that is broadly expressed in neurons. Technology description Dr William A Catterall’s laboratory has generated continuous mammalian somatic cell lines expressing genes encoding voltage-sensitive sodium channel subunits Nav1.2. The cell lines provide a convenient tool for screening of drugs selective for individual sodium channel subtypes. Related Publication(s)
Neuron 1988 1:449–461. Proc. Natl. Acad. Sci. USA 1987 84:8682-8686. Proc. Natl. Acad. Sci. USA 1986 83:7503-7507. For more information on this technology contact:
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