The Gene Encoding the Drosophila Muscarinic Acetylcholine Receptor & Its Expression in Mammalian Cells

Introduction Muscarinic acetylcholine receptors are involved in the activation of various signal transduction pathways through their interaction with G protein. They play a major role in regulating the functions of the target organs of the parasympathetic nervous system of mammals. Acethylcholine is also a major excitatory transmitter of the central nervous system of insects. Technology description Dr Neil M. Nathanson’s laboratory has isolated genomic and cDNA clones encoding a muscarinic acetylcholine receptor from Drosophila melanogaster. A full-length cDNA clone has been placed under the control of the mouse metallothionein promotor and transfected into mouse Y1 adrenal cells. The Drosophila muscarinic receptor, when expressed in Y1 cells, is physiologically active, as measured by agonist-dependent stimulation of phosphatidylinositol metabolism. This cell line is a useful tool for screening new compounds for neurotoxic insecticidal activity. Related Publication(s)
Proc Natl Acad Sci U S A. 1989 November; 86(22): 9039–9043. For more information on this technology contact:
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