Dice1.1 and Dice1.2 congenic mice
Technology description Dice1.1 and Dice1.2 inbred congenic mouse strains were produced on a BALB/c background and contain discrete non-overlapping chromosome 16 congenic intervals inherited from B10.D2. These congenic intervals contain genetic loci that control the propensity of CD4+ helper T cells to produce IL4 and become TH2 cells. In addition, the Dice1.2 locus (or a tightly-linked locus) controls susceptibility to the infectious protozoal parasite (Leishmania major) that causes cutaneous leishmaniasis. Together these strains provide the raw materials: 1/ for identifying the Dice1.1 and Dice1.2 genes controlling TH2 bias and susceptibility to leishmaniasis; 2/ the raw materials for identifying genetic loci controlling other TH2 bias-dependent diseases, such as allergic asthma, multiple sclerosis, diabetes, atherosclerosis, diabetes, multiple sclerosis, leprosy, etc.; 3/ the raw materials for studying the cellular and molecular contribution of the Dice1.1 and Dice1.2 genes to various infections and autoimmune disease states; 4/ for studying the epistatic interactions of Dice1.1 and Dice1.2 with each other and other identified genetic components of the multigenic disease susceptibility phenotypes describes in 2/; 5/ in vivo models to test the mechanism and efficacy of pharmaceutical compounds on cutaneous leishmaniasis and the other disease states mentioned in 2/. Related Publication(s)J Exp Med. 2004 Dec 20;200(12):1605-12 For more information on this technology contact:
Ariadna Santander Agreements Manager Technology Licensing [email protected] 206-543-1138
Type of Offer: Licensing
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