Phospholipase C-γ1 Fusion Protein Constructs

Introduction Phosphoinositide phospholipase C (PLC) is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. PLCs participate in phosphatidylinositol bisphosphate (PIP2) metabolism and lipid signaling pathways in a calcium-dependent manner. Phospholipase C-γ1 (PLC-γ1) is recognized for its role in growthfactor- dependent signal transduction. Its Src-homology 2 (SH2) domains mediate the association of PLC-γ with tyrosine-phosphorylated proteins, especially activated growthfactor- receptor tyrosine kinases. Technology description Dr Edward Clark’s laboratory has produced Glutathione S-transferase (GST) fusion protein constructs containing either the N-terminal [GST- γ 1SH2(N)], the C-terminal [GST- γ
1SH2(C)], or both [GST- γ 1SH2(NC)] SH2 domains of PLC-γ1. In addition, GST fusion proteins containing either Tyr-472 [GST- γ 1Y472] or Tyr-771 and Tyr-783 [GST- γ
1Y771,Y783] of PLC-γ1 are also available. Related Publication(s)
Mol. Cell Biol. 1996 Apr; 16(4): 1305--15 For more information on this technology contact:
Ariadna Santander Agreements Manager Technology Licensing [email protected] 206-543-1138

Type of Offer: Licensing



« More Science Patents

---