Nav1.2/β1/contactin cell line

Introduction Mammalian Na+ channels are heteromultimeric structures that include the poreforming
α subunit in association with auxiliary β subunits. Contactin is a neuronal cell adhesion molecule of the immunoglobulin superfamily. Numerous lines of evidence indicate a role for contactin in regulating functional expression and distribution of Na+
channels in neurons. Technology description Dr William A Catterall’s laboratory has constructed a stable line of NaIIAβ1 cells expressing rat Nav1.2α and β1 sodium channel subunits in addition to contactin. The cell line is resistant to the antibiotics G418 and Zeocin. Nav1.2/β1/contactin cells have threefold to fourfold higher peak Na+ currents than cells with Nav1.2α alone, Nav1.2/β1, Nav1.2/contactin, or Nav1.2/β1/ β2. These cells also have a correspondingly higher saxitoxin binding, suggesting an increased Na+ channel surface membrane density. Related Publication(s)
J. Neurosci. 21:7517-7525, 2001. For more information on this technology contact:
Ariadna Santander Agreements Manager Technology Licensing [email protected] 206-543-1138

Type of Offer: Licensing



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