Composition and method of preparation of lipid nano particulates containing antigens as cancer vaccine
Using a rational design strategy, compositions (LINAP) have been developed for the targeted delivery of cancer vaccine antigens. Designed to target Dendritic cells (DC), LINAP is able to facilitate more potent T-cell immune responses than immunizing with antigens alone. In addition, LINAP confers stability to otherwise unstable vaccine antigens, thereby allowing for a completely in vivo vaccination protocol. As a result, LINAP is significantly less complex than existing DC-based vaccine stra tegies while also being more versatile: LINAP can be used for patient-specific or off-the-shelf cancer vaccines.
Categories: Nanotechnology, Therapeutic and Vaccines
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