Method and composition of Pegylated protein (FVIII)-Phosphoserine complex

These novel compositions provide for enhanced delivery of protein therapeutics. Proteins (e.g. recombinant Factor VIII) associated with LIPRO-FORM exhibited improved pharmacokinetic profiles and higher efficacies in animal models. With characterist ics such as lowered immunogenicity and increased circulation time, LIPRO-FORM provides significant potential advantages including a reduction in the frequency of administration, an abatement of inhibitor development and an extension of patent life.

Categories: Therapeutic and Vaccines

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