Using Selection to Define Rules for Small Molecule Targeting of RNA

Information needed to design nucleic acid-based compounds which target RNA can be as limited as knowing the Watson-Crick base pairing “code”. However, to date, the clinical success of such compounds (e.g. antisense and RNAi) has been elusive. Unlike nucleic acid-based drug candidates, delivery and stability of small molecules is not as significant an issue, making them more likely to progress through the development path, but designing them to target RNA is far more complicated due to the lack of a chemical “code” for recognition binding of RNA. RNArray is an enabling technology that provides a means for identifying RNA structural motifs which bind to specific organic ligands, thereby establishing a chemical “code” that can be used to sea rch an intended RNA for targetable structural motifs and for the design of small molecule drugs that target such structures. Unlike SELEX™, which establishes the feasibility of finding organic ligands that bind RNA, RNArray allows for parallel scree ning of multiple libraries while eliminating the need for iterative cycles of selection and amplification, resulting in savings of time, labor and materials.

Categories: Therapeutic and Vaccines, Research Tool

Type of Offer: Licensing



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