Biological Vaccine Delivery System
This invention relates to methods and compositions for producing a fusion protein comprised of Haemophilus influenae P2 amino acid sequences, wherein in place of loop 5, or a portion thereof, is displayed a heterologous or homologous peptide sequence having biological activity. The protrusion of loop 5 from the P2 sequence allows for proper presentation of the fused antigen, and hence an enhanced immune response. The fusion protein may be expressed on the surface of the host cell, such as in H. influenzae. Alternatively, the fusion protein can be purified from the host cell in the expression system if it remains associated with the cell or purified from the media if it is secreted.
Categories: Biomedical Engineering, Therapeutic and Vaccines
Patents Issues: 6,033,877
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