Novel Human Gene with Immunoregulatory and Antiproliferative Properties

Abnormal or unregulated control of the body’s immune system can contribute to a variety of disorders, including but not limited to autoimmune disease and cancer. Standard treatments for autoimmune disease involve administration of non-steroidal anti- inflammatory drugs, corticosteroids, and disease modifying anti-rheumatic drugs. Unfortunately, long-term treatment with these drugs can cause unwanted side effects and toxicity. The newest and most promising class of drugs includes proteins that i nfluence the inflammatory process by counteracting cytokines such as tumor necrosis factor alpha (TNF-alpha). Physicians affiliated with the University at Buffalo have identified a novel human gene and its corresponding protein, which function in th e regulation of host immune responses. In early in vivo studies, the protein was found to abrogate immune responses following antigenic challenge even when administered topically.

Categories: Genomics, Therapeutic and Vaccines Patents Issues: 7,253,148

Type of Offer: Licensing



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