Inhibition of Mechanical Ion Channels by Peptide Enantiomers

Stretch-activated cation channels (SAC) are wide-spread in the body and trigger cellular responses to mechanical stresses. They mediate the senses of touch and hearing and help to regulate organ functions. GsMTx4, a tarantula venom peptide, and its enantiomer selectively block SAC channels. By blocking the SAC channels, GsMTx4 offers a potentially powerful therapy for arrhythmia, congestive heart failure, incontinence, muscular dystrophy and other possibilities.

Categories: Research Tool, Therapeutic and Vaccines

Patents Issues: 7,259,145

Type of Offer: Licensing



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