Metal Coated Magnetic Nanoparticles (MCMNP) and their application to chemical/biochemical detection
This technology is a new synthetic method for manufacturing MCMNP. MNMNP are an enabling component of optical spectroscopic techniques, which are currently limited because of their relative susceptibility to spectral interference from chemicals present in the sample matrix and/or from low detection sensitivity. Thus, costly and lengthy sample purification and concentration/magnification is a common requisite to optical detections.
Advantages High detection sensitivity: Three factors work constructively for the higher detection sensitivity using MCMNP 1. analyte concentration 2. reduced spectral interference 3. electromagnetic enhancement Lower material cost and labor: MCMNP allows in-situ sample concentration, purification, and spectral acquisition. Multiplex: MCMNP can be easily adopted into an array format for multiplex sample analysis. Quantitative: Highly accurate quantitative measurements can be achieved for comparative protein or gene expression studies, facilitating biomarker detection.
Potential Applications The techniques and devices described in this invention are applicable to surface enhanced Raman spectroscopy (SERS), surface enhanced fluorescence (SEF), and surface enhanced infrared absorption (SEIRA) applications. Specifically, this technology enables simple, fast, ultrasensitive quantitative and/or qualitative detection of chemicals and biochemicals, including DNA and protein, with exceedingly high sensitivity. It can be used for disease diagnostics, disease marker discovery, forensic analysis, and other clinical, biomedical and biological applications.
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