Platelet Polymorphism PI-A2

A method for diagnosing a subject having or at risk of having a thrombotic disease syndrome is provided by analysis of a platelet polymorphism. Specifically, the association between polymorphism of the P1A2 allele of the GPIIIa gene and unstable thrombotic syndromes provides the basis for methods and kits for diagnosing subjects. Description (Set) Proposed Use (Set) The invention provides isolated allele specific oligonucleotides useful for the diagnosis of a subject having, or at risk of having, a thrombotic disease syndrome, e.g., heart disease, acute coronary artery thrombosis, myocardial infarction (MI) or unstable angina (USA). The DNA used in the test method may be extracted from a body sample, such as blood, tissue material and the like by a variety of techniques. In a preferred aspect of the invention, P1A2 polymorphism is detected by the reverse dot blot hybridization technique (RDB). Patent (Set) 5,955,266

US 5,955,266

Inventor(s): Bray, Paul F.

Type of Offer: Licensing

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