Urease-Responsive Delivery Systems for Diagnostic and Therapeutic Applications
The present invention provides novel compositions and methods for diagnosing the presence of Helicobacter pylori infections of the stomach or duodenum in humans or other mammals. The invention provides a urease responsive system for the delivery of diagnostic marker or therapeutic compound. In one embodiment, the system comprises a microsphere which is stabilized by a urease sensitive cross-linker. When the cross-linker is cleaved by urease, the microsphere decomposes and the diagnostic marker or therapeutic compound is released. In a preferred embodiment, the microsphere is a gelatin composition, but it may also be formulated from other biocompatible hydrogels or water soluble polymers which can be cross linked by a urease-sensitive compound.
Leong, Kam W
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