An Assay for Determining Subunit Interaction in Ion Channels
The present invention relates to compounds and related methods for both inhibiting and potentiating potassium ion channel activity. In particular, a molecular code of the alpha-subunit in a Shaker-like potassium ion channel was identified that provides for the beta-subunit-mediated regulation of potassium ion flow. Methods to identify novel molecules that regulate this critical region are also provided by the present invention. Description (Set) Proposed Use (Set) One valuable use is the development of new therapeutics involving the regulation of potassium ion channels in excitable and nonexcitable cells (e.g., cardiac function, neurotransmitter function, and hormone secretion).
Patent (Set) 5,856,155;
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