Autologous GVHD

Portions of the MHC class II invariant chain peptide, termed CLIP, exhibit immunomodulatory properties and can skew the cytokine response. In particular, the flanking regions of CLIP interact with receptors on the T lymphocyte surface. Polypeptides engineered to comprise different sub-sequences of the CLIP molecule can be used to modulate immune responses to specific targets including tumor-associated antigens. Depending upon the particular subsequence of CLIP chosen for the polypeptide construct, the immune response to a target may be enhanced or diminished. Description (Set) Proposed Use (Set) The invention may be used to target the immune response to desired tumor-associated antigens.

Patent (Set) 6,326,465

Patents:
US 6,326,465

Inventor(s): Hess, Allan

Type of Offer: Licensing



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