Brain Stimulation as a Treatment for Seizures

The present invention includes adaptive technologies to detect and treat brain seizures. Neural networks or other mathematical methods which model seizure patterns are used to detect the seizures. A number of methods for simulation are suggested which include increasing the output of inhibitory structures, decreasing excitation, stimulating targets that would block epileptogenic activity, and interfering with the synchronization of the ictal firing pattern. Different pulse sequences and/or DC shifts are used in stimulating the brain. Both sites of stimulation as well as manner of stimulation are customized for each patient. Description (Set) Proposed Use (Set) The key benefit of this technology is the idea of customization. Previous work in the field has lacked success due to utilization of the same techniques for treatment in all patients. With this technology, site and method of stimulation is patient specific. Problem Solved/Background: Seizures are the result of abnormal electrical discharge in the brain which can cause temporary change in sensation, behavior, movement, or consciousness. Epilepsy is a chronic disorder characterized by a tendency to have recurrent seizures. There have been multiple publications regarding stimulation of single inhibitory structures as a treatment for seizures; however results have not been convincing. Currently there is one commercial product for the treatment of seizures, the Vagal Nerve Stimulator (VNS).

Patent (Set) 754269; 1047362; WO 99/34758; 6,248,126; 69921449.1-08

US 754,269

Inventor(s): Lesser, Ronald Peter

Type of Offer: Licensing

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