A New Human p53 Homologue (p46)

Since its identification as a tumor suppressor gene, p53 has become one of the most studied genes in human cancer. Inactivation of p53 is though to represent the most common genetic event in all neoplasms and may contribute to the development of 50% of all human cancers. Because of p53?s role in DNA repair and apoptosis, an extensive search has been conducted for other members of the p53 family and other components of the p53 signaling pathway. Johns Hopkins researchers have designed degenerate primers to the DNA binding region of both the p53 gene and its homologue p73 and amplification of cDNA form the bladder carcinoma cell line 1472 revealed a predominant band. The gene product was subcloned, sequenced and the full-length gene cloned by hybridization, inverse PCR and BAC sequencing. This gene is homologous to p53 and p73 in the DNA binding and transcriptional activator domains.

Inventor(s): Sidransky, David

Type of Offer: Licensing



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