Methylated CpG Island Amplification (MCA)
Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in neoplasia. JHU scientists have developed a novel method of understanding patterns of CpG island methylation called Methylated CpG island Amplification (MCA). MCA is a PCR-based methylation screening technique to determine the methylation status of multiple CpG islands (CGIs) in a relatively large number of samples. Description (Set) Proposed Use (Set) This technology could be utilized commercially as a diagnostic method to screen for specific cancers and age associated disorders. Additionally this method could be utilized to screen for cancer and age associated disorder responses to drugs/agents.
Patent (Set) WO 00/26401; 774774
Baylin, Stephen B.
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