Identification of DNA Sequences Differentially Methylated in Pancreatic Cancer

Researchers at Johns Hopkins University have used the techniques of methylated CpG island amplification (MCA) coupled with representational difference analysis (RDA) to isolate 42 clones, which were shown to be differentially methylated in a panel of 8 pancreatic cancer cell lines compared to normal pancreas. Ninety-five percent of the clones were CpG islands and among these clones were CpG islands of several known genes. The genes identified may represent novel targets for pancreatic cancer treatment or serve as diagnostics for the detection of early stage pancreatic cancer. Patent (Set) 7,153,653 B2; WO 02/068694

US 7,153,653

Inventor(s): Goggins, Michael

Type of Offer: Licensing

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