Use of Proaerolysin Toxins Modified to Contain Tissue Specific Protease Activation Sequences as Targeted Therapy for Cancer

Proaerolysin is a bacterial toxin that is normally activated by furin protease to produce the pore forming toxin aerolysin which is toxic to prostate cancer cells at picomolar concentrations. We have removed the furin activation site and replaced it with a site that is recognized by the serine protease prostate-specific antigen (PSA) to produce a protoxin that is selectively activated within sites of prostate cancer Description (Set) Proposed Use (Set) Therapy for prostate cancer

Inventor(s): Denmeade, Samuel

Type of Offer: Licensing



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