Collagen Mimetic Peptides for Imaging and Therapy

Abstract (Set) Collagens, the most abundant protein in mammals, provide a structural framework during tissue development and repair. Functionalized collagen that incorporates exogenous compounds may offer new and improved biomaterials applications, especially in drug delivery, multifunctional implants and tissue engineering. A simple, novel, specific, and reversible collagen modification technique with minimum biochemical and structural perturbation of the native collagen provides for synthetic collagen mimetic peptides (CMP) that can interact specifically with native collagen (JHU Ref. C04571). JHU scientists have synthesized a series of collagen mimetic peptides of low molecular weight that can be functionalized with a variety of chemical moieties for imaging and therapy. These compounds are tunable and can have slightly different structures enabling their use under various conditions (in vitro and in vivo) and for various indications such as cancer, cardiovascular disease, connective tissue disorder, wound healing, and other disorders in which the collagen matrix is disrupted or plays an important role. Description (Set) Features/Benefits ? Novel composition of matter. ? Functionalized peptides enable imaging of the tumor microenvironment useful for cancer diagnostics and therapy. ? Functionalized peptides enable imaging to study pathogenesis of atheroma formation in at risk patients useful for early diagnosis of heart disease. ? Functionalized peptides enable delivery of pharmaceutical products (drugs, radionuclides, antimicrobials, anti-inflammatory, etc.) for treatment of disease. Proposed Use (Set) In vivo imaging and diagnostic imaging for cancer, cardiovascular disease, and collagen disorders.

Inventor(s): Yu, Michael ,Wang, Allen Yi-Lan,Foss, Catherine

Type of Offer: Licensing



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