miRNA Microarray Analysis in Barrett's Esophagus and Esophageal Adenocarcinoma

Description (Set) JHU scientists have discovered independent microRNA specific for Barrett?s esophagus (BE) and Esophageal adenocarcinoma (EAC). These EAC and BE microRNA could be used as diagnostic and prognostic biomarkers. EAC is a lethal condition with a very low 5-year survival rate. EAC and its precursor, Barrett?s esophagus (BE), can be asymptomatic and undetected until a late stage of development. JHU scientists have discovered differential expression of multiple microRNA among EAC and BE cell lines and control esophageal cells. Biomarker expression could be used to detect and/or predict BE and EAC in asymptomatic patients and select those needing further endoscopic surveillance and/or diagnosis. Screening for expression of these microRNA in patients could be efficiently done with microarray assays. Using EAC- and BE- specific biomarkers in a diagnostic test is an improvement over currently used invasive endoscopic screening procedures. Proposed Use (Set) This technology can be commercialized as diagnostic and prognostic biomarkers and assays for detection and early diagnosis of BE and EAC. These biomarkers meet a long felt need for a more efficient tool for early detection and surveillance of BE for successful intervention in EAC development. A microRNA detection assay is potentially cheaper, less invasive, more efficient, more specific, and more robust than methods currently used.

Inventor(s): Meltzer, Stephen

Type of Offer: Licensing



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